RB-400 [Ligand Id: 900] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL262197 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cholecystokinin A receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3501] [UniProtKB: Q63931] | ||||||||
| ChEMBL | Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranes | B | 9.12 | pKi | 0.75 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 369-372 [PMID:14698161] |
| ChEMBL | Affinity against Cholecystokinin type A receptor on guinea pig pancreatic membranes. | B | 9.15 | pKi | >0.7 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| ChEMBL | Binding affinity against cholecystokinin type B receptor on guinea pig cortex. | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| ChEMBL | Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells | B | 5.52 | pKi | >3000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 369-372 [PMID:14698161] |
| GtoPdb | - | - | 9.1 | pKi | 0.79 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 369-72 [PMID:14698161] |
| ChEMBL | Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain. | B | 9.12 | pKi | 0.75 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| ChEMBL | Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain. | F | 9.4 | pEC50 | 0.4 | nM | EC50 | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
