teduglutide   Click here for help

GtoPdb Ligand ID: 7049

Synonyms: ALX-0600 | Gattex® | GLP2-2G | Revestive®
Approved drug Immunopharmacology Ligand
teduglutide is an approved drug (FDA and EMA (2012))
Comment: Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue in which position 2 amino acid alanine is replaced by glycine, increasing the peptide's resistance to proteolytic cleavage by dipeptidyl peptidase-4 (DPP-4) [2]. The chemical structure of teduglutide is represented in the PubChem and ChEMBL entries listed below. The intestinotrophic effects of GLP-2 (e.g. promotion of intestinal growth, reduced epithelial cell apoptosis and inflammation) has led to the development of GLP-2 analogues like teduglutide for the treatment of GI disorders such as short bowel syndrome and inflammatory bowel diseases.
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Classification Click here for help
Compound class Peptide or derivative
Approved drug? Yes (FDA and EMA (2012))
International Nonproprietary Names Click here for help
INN number INN
8444 teduglutide
Synonyms Click here for help
ALX-0600 | Gattex® | GLP2-2G | Revestive®
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 710
Other databases
CAS Registry No. 197922-42-2
ChEMBL Ligand CHEMBL2104987
DrugBank Ligand DB08900
GtoPdb PubChem SID 178103628
PubChem CID 16139605
Search PubMed clinical trials teduglutide
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Wikipedia Teduglutide