CCK-8 [Ligand Id: 864] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1121 (Cck-8, Cck c-terminal octapeptide, Cholecystokinin, Cholecystokinin c-terminal octapeptide, Kinevac, Pancreozymin, Sincalide, SQ 19844, SQ-19844) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238] | ||||||||
| ChEMBL | Displacement of radiolabeled CCK-8s from human CCK1 receptor | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | In vitro for binding affinity against human cholecystokinin type A receptor. | B | 8.88 | pIC50 | 1.32 | nM | IC50 | J Med Chem (1997) 40: 2706-2725 [PMID:9276016] |
| ChEMBL | Binding affinity against human Cholecystokinin type A receptor by displacement of [125I]CCK-8 | B | 8.88 | pIC50 | 1.32 | nM | IC50 | J Med Chem (1996) 39: 2655-2658 [PMID:8709093] |
| ChEMBL | Binding affinity against human Cholecystokinin type A receptor in membrane preparation isolated from CHO-K1 cells stably transfected with cDNA of human CCK-A using [125I]-Bolton-Hunter CCK-8 as radioligand | B | 8.88 | pIC50 | 1.32 | nM | IC50 | J Med Chem (1996) 39: 3030-3034 [PMID:8709137] |
| ChEMBL | Tested for the 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type A receptor | B | 8.9 | pIC50 | 1.26 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 511-514 |
| ChEMBL | Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type A receptor | B | 9.2 | pIC50 | 0.63 | nM | IC50 | J Med Chem (1996) 39: 5236-5245 [PMID:8978852] |
| ChEMBL | Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type A receptor stably expressed in CHO-K1 cells | B | 9.2 | pIC50 | 0.63 | nM | IC50 | J Med Chem (1996) 39: 562-569 [PMID:8558528] |
| ChEMBL | Displacement of CCK-8 from CHO cell membranes expressing human Cholecystokinin type A receptor | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (1995) 38: 207-211 [PMID:7837233] |
| ChEMBL | In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type A receptor expressed in CHO-K1 cells | B | 9.41 | pIC50 | 0.39 | nM | IC50 | J Med Chem (1995) 38: 3384-3390 [PMID:7650691] |
| ChEMBL | Displacement of radiolabeled CCK-8s from human CCK1 receptor | B | 9.43 | pIC50 | 0.37 | nM | IC50 | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | Displacement of [125I]CCK-8s from human recombinant CCK-A receptor expressed in CHO cells | B | 9.89 | pIC50 | 0.13 | nM | IC50 | Bioorg Med Chem (2016) 24: 1793-1810 [PMID:26988801] |
| ChEMBL | Displacement of [125I]CCK-8s from human recombinant CCK1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method | B | 9.89 | pIC50 | 0.13 | nM | IC50 | Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250] |
| ChEMBL | Displacement of [125I]-CCK-8 from human CCK1R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay | B | 9.95 | pIC50 | 0.11 | nM | IC50 | J Med Chem (2019) 62: 1407-1419 [PMID:30624060] |
| ChEMBL | Antagonist activity at CCK1 receptor expressed in HEK 293 cells assessed as accumulation of [3H]inositol phosphates by PI assay | F | 7.55 | pEC50 | 28.18 | nM | EC50 | J Med Chem (2006) 49: 2868-2875 [PMID:16686530] |
| ChEMBL | Antagonist activity at CCK1 receptor expressed in HEK 293 cells assessed as accumulation of [3H]inositol phosphates by PI assay | F | 7.55 | pEC50 | 28 | nM | EC50 | J Med Chem (2006) 49: 2868-2875 [PMID:16686530] |
| ChEMBL | Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type A receptor | B | 10 | pEC50 | 0.1 | nM | EC50 | J Med Chem (1995) 38: 3384-3390 [PMID:7650691] |
| ChEMBL | Agonist activity at human CCK1R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay | F | 10.36 | pEC50 | 0.04 | nM | EC50 | J Med Chem (2019) 62: 1407-1419 [PMID:30624060] |
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | Evaluated for binding affinity measured by inhibiting [3H]Boc[Nle28,31]CCK27-33 specific binding to Cholecystokinin receptor in rat pancreas membranes at a KD concentration of 4.4 nM | B | 8.06 | pKi | 8.71 | nM | Ki | J Med Chem (1987) 30: 962-968 [PMID:2438407] |
| ChEMBL | Inhibition of [3H]pCCK-8 specific binding to Cholecystokinin type A receptor of rat pancreas | B | 9.28 | pKi | 0.52 | nM | Ki | J Med Chem (1997) 40: 3402-3407 [PMID:9341915] |
| ChEMBL | Binding affinity for Cholecystokinin type A receptor using [125I]BH-CCK-8 in rat pancreatic tissue | B | 10.05 | pKi | 0.09 | nM | Ki | J Med Chem (1997) 40: 4302-4307 [PMID:9435899] |
| ChEMBL | Inhibition of [125I]BH-CCK-8 binding to Cholecystokinin type A receptor of rat pancreatic tissue | B | 10.05 | pKi | 0.09 | nM | Ki | J Med Chem (2000) 43: 2350-2355 [PMID:10882360] |
| GtoPdb | - | - | 7.2 | pIC50 | - | - | - | Proc Natl Acad Sci USA (1990) 87: 6728-32 [PMID:1975695] |
| ChEMBL | Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat pancreas membrane(CCK-A) | B | 8.97 | pIC50 | 1.08 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 855-860 |
| ChEMBL | Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type A receptor from rat pancreas | B | 8.98 | pIC50 | 1.04 | nM | IC50 | J Med Chem (1999) 42: 4659-4668 [PMID:10579828] |
| ChEMBL | Inhibition of [3H]pCCK-8 binding to cholecystokinin type A receptor of rat pancreas | B | 8.98 | pIC50 | 1.04 | nM | IC50 | J Med Chem (2001) 44: 4196-4206 [PMID:11708921] |
| ChEMBL | Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type A receptor of rat pancreas homogenates | B | 8.98 | pIC50 | 1.04 | nM | IC50 | J Med Chem (2004) 47: 5318-5329 [PMID:15456276] |
| ChEMBL | Compound was evaluated for the binding affinity towards rat pancreatic Cholecystokinin type A receptor | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1245-1248 [PMID:10866391] |
| ChEMBL | Displacement of 125I]-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat cell membrane Cholecystokinin type A receptor | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 3127-3132 [PMID:9873689] |
| ChEMBL | Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini | B | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (1992) 35: 28-38 [PMID:1732532] |
| GtoPdb | - | - | 9.9 | pIC50 | - | - | - | Proc Natl Acad Sci USA (1990) 87: 6728-32 [PMID:1975695] |
| ChEMBL | Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type A receptor of rat pancreas | B | 10 | pIC50 | 0.1 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 889-894 |
| ChEMBL | Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to rat pancreas cholecystokinin type A receptor | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (1991) 34: 404-414 [PMID:1671419] |
| ChEMBL | Evaluated for inhibition of cholecystokinin type A receptor by displacing [125I]bolton hunter CCK-8 radioligand in the rat pancreas | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (1992) 35: 2573-2581 [PMID:1635058] |
| ChEMBL | Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas. | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (1993) 36: 552-565 [PMID:7684452] |
| Cholecystokinin A receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3501] [UniProtKB: Q63931] | ||||||||
| ChEMBL | Displacement of [3H]-pCCK-8 from cholecystokinin-A receptor in guinea pig pancreatic membrane | B | 9.15 | pKi | 0.7 | nM | Ki | J Med Chem (1993) 36: 166-172 [PMID:8421283] |
| ChEMBL | Compound was tested for binding affinity against CCK1 (cholecystokinin) receptor on guinea pig pancreatic membranes | B | 9.15 | pKi | 0.7 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| ChEMBL | The compound was tested for the inhibition of [3H]propionyl specific binding to CCK-8 receptor of guinea pig pancreatic membrane | B | 9.19 | pKi | 0.64 | nM | Ki | J Med Chem (1989) 32: 445-449 [PMID:2464062] |
| ChEMBL | Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type A receptor in pancreatic membranes of guinea-pig | B | 9.19 | pKi | 0.64 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 847-850 |
| ChEMBL | Displacement of 0.1 nM [3H]pCCK-8 from guinea pig pancreatic membranes | B | 9.19 | pKi | 0.64 | nM | Ki | J Med Chem (1989) 32: 1184-1190 [PMID:2724293] |
| ChEMBL | Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranes | B | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 369-372 [PMID:14698161] |
| ChEMBL | Inhibition of [3H]pCCK-8 binding to Cholecystokinin type A receptor of Guinea pig pancreatic membranes | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (1997) 40: 647-658 [PMID:9057851] |
| ChEMBL | The compound was tested for the inhibition of [3H]propionyl specific binding to CCK-8 receptor of guinea pig brain | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (1989) 32: 445-449 [PMID:2464062] |
| ChEMBL | Displacement of [125I]BH-CCK-8 from Cholecystokinin type A receptor in guinea pig pancreas | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (1990) 33: 2950-2952 [PMID:1700123] |
| ChEMBL | Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig pancreas Cholecystokinin type A receptor | B | 9.55 | pIC50 | 0.28 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 855-860 |
| CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| ChEMBL | The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex. | B | 9.19 | pKi | 0.65 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 885-888 |
| ChEMBL | Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor | B | 9.19 | pKi | 0.64 | nM | Ki | J Med Chem (1997) 40: 647-658 [PMID:9057851] |
| ChEMBL | Displacement of radiolabeled CCK-8s from human CCK2 receptor | B | 9.43 | pKi | 0.37 | nM | Ki | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane | B | 9.52 | pKi | 0.3 | nM | Ki | J Med Chem (1993) 36: 166-172 [PMID:8421283] |
| ChEMBL | Binding affinity against cholecystokinin type B receptor on guinea pig cortex. | B | 9.52 | pKi | 0.3 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| ChEMBL | Inhibitory activity against Cholecystokinin type B receptor | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 799-802 |
| ChEMBL | Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain | B | 9.55 | pKi | 0.28 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 847-850 |
| ChEMBL | Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (1989) 32: 1184-1190 [PMID:2724293] |
| ChEMBL | Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex | B | 8.09 | pIC50 | 8.2 | nM | IC50 | J Med Chem (1990) 33: 2950-2952 [PMID:1700123] |
| ChEMBL | Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor | B | 8.8 | pIC50 | 1.6 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 855-860 |
| ChEMBL | Displacement of radiolabeled CCK-8s from human CCK2 receptor | B | 9.04 | pIC50 | 0.92 | nM | IC50 | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand | B | 9.46 | pIC50 | 0.35 | nM | IC50 | J Med Chem (1996) 39: 3030-3034 [PMID:8709137] |
| ChEMBL | In vitro for binding affinity against human cholecystokinin type B receptor. | B | 9.46 | pIC50 | 0.35 | nM | IC50 | J Med Chem (1997) 40: 2706-2725 [PMID:9276016] |
| ChEMBL | Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor | B | 9.5 | pIC50 | 0.32 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 511-514 |
| ChEMBL | Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor | B | 9.5 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1996) 39: 5236-5245 [PMID:8978852] |
| ChEMBL | Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells | B | 9.5 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1996) 39: 562-569 [PMID:8558528] |
| ChEMBL | Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes | B | 9.5 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1995) 38: 207-211 [PMID:7837233] |
| ChEMBL | In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells | B | 9.5 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1995) 38: 3384-3390 [PMID:7650691] |
| ChEMBL | Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay | B | 9.54 | pIC50 | 0.29 | nM | IC50 | J Med Chem (2019) 62: 1407-1419 [PMID:30624060] |
| ChEMBL | Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8 | B | 9.64 | pIC50 | 0.23 | nM | IC50 | J Med Chem (1996) 39: 2655-2658 [PMID:8709093] |
| ChEMBL | Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells | B | 9.92 | pIC50 | 0.12 | nM | IC50 | Bioorg Med Chem (2016) 24: 1793-1810 [PMID:26988801] |
| ChEMBL | Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method | B | 9.92 | pIC50 | 0.12 | nM | IC50 | Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250] |
| GtoPdb | - | - | 10 | pIC50 | - | - | - |
J Biol Chem (1993) 268: 8164-9 [PMID:7681836]; J Biol Chem (1993) 268: 18300-5 [PMID:8349705] |
| ChEMBL | Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay | F | 7.57 | pEC50 | 27 | nM | EC50 | J Med Chem (2006) 49: 2868-2875 [PMID:16686530] |
| ChEMBL | Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay | F | 7.57 | pEC50 | 26.92 | nM | EC50 | J Med Chem (2006) 49: 2868-2875 [PMID:16686530] |
| ChEMBL | Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay | F | 9.3 | pEC50 | 0.5 | nM | EC50 | J Med Chem (2019) 62: 1407-1419 [PMID:30624060] |
| ChEMBL | Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells | B | 10.03 | pEC50 | 0.09 | nM | EC50 | J Nat Prod (2006) 69: 432-435 [PMID:16562853] |
| ChEMBL | Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor | B | 10.3 | pEC50 | 0.05 | nM | EC50 | J Med Chem (1995) 38: 3384-3390 [PMID:7650691] |
| CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481] | ||||||||
| ChEMBL | In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay | B | 8.89 | pIC50 | 1.3 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 705-709 [PMID:11266174] |
| ChEMBL | Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Med Chem (1992) 35: 2573-2581 [PMID:1635058] |
| ChEMBL | Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Med Chem (1993) 36: 552-565 [PMID:7684452] |
| ChEMBL | Binding affinity towards Cholecystokinin type B receptor in mouse cortex membrane | B | 9.52 | pIC50 | 0.3 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1245-1248 [PMID:10866391] |
| ChEMBL | Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Med Chem (1991) 34: 404-414 [PMID:1671419] |
| ChEMBL | Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex | B | 9.52 | pIC50 | 0.3 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 889-894 |
| CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| ChEMBL | Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes | B | 8.55 | pKi | 2.8 | nM | Ki | J Med Chem (1997) 40: 3402-3407 [PMID:9341915] |
| ChEMBL | Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells | B | 9.15 | pKi | 0.7 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 369-372 [PMID:14698161] |
| ChEMBL | Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1997) 40: 647-658 [PMID:9057851] |
| ChEMBL | Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain. | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| ChEMBL | Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes | B | 9.39 | pKi | 0.41 | nM | Ki | J Med Chem (1997) 40: 4302-4307 [PMID:9435899] |
| ChEMBL | Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand | B | 9.39 | pKi | 0.41 | nM | Ki | J Med Chem (2000) 43: 2350-2355 [PMID:10882360] |
| ChEMBL | Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B) | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 855-860 |
| ChEMBL | Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane | B | 8.25 | pIC50 | 5.6 | nM | IC50 | J Med Chem (1999) 42: 4659-4668 [PMID:10579828] |
| ChEMBL | Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex | B | 8.25 | pIC50 | 5.6 | nM | IC50 | J Med Chem (2001) 44: 4196-4206 [PMID:11708921] |
| ChEMBL | Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates | B | 8.25 | pIC50 | 5.6 | nM | IC50 | J Med Chem (2004) 47: 5318-5329 [PMID:15456276] |
| ChEMBL | Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1992) 35: 28-38 [PMID:1732532] |
| ChEMBL | Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor | F | 9.2 | pEC50 | 0.63 | nM | EC50 | J Med Chem (1997) 40: 647-658 [PMID:9057851] |
| ChEMBL | Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain. | F | 9.2 | pEC50 | 0.63 | nM | EC50 | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
