CCK-8 [Ligand Id: 864] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1121 (Cck-8, Cck c-terminal octapeptide, Cholecystokinin, Cholecystokinin c-terminal octapeptide, Kinevac, Pancreozymin, Sincalide, SQ 19844, SQ-19844) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238] | ||||||||
| ChEMBL | Displacement of radiolabeled CCK-8s from human CCK1 receptor | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | In vitro for binding affinity against human cholecystokinin type A receptor. | B | 8.88 | pIC50 | 1.32 | nM | IC50 | J Med Chem (1997) 40: 2706-2725 [PMID:9276016] |
| ChEMBL | Binding affinity against human Cholecystokinin type A receptor by displacement of [125I]CCK-8 | B | 8.88 | pIC50 | 1.32 | nM | IC50 | J Med Chem (1996) 39: 2655-2658 [PMID:8709093] |
| ChEMBL | Binding affinity against human Cholecystokinin type A receptor in membrane preparation isolated from CHO-K1 cells stably transfected with cDNA of human CCK-A using [125I]-Bolton-Hunter CCK-8 as radioligand | B | 8.88 | pIC50 | 1.32 | nM | IC50 | J Med Chem (1996) 39: 3030-3034 [PMID:8709137] |
| ChEMBL | Tested for the 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type A receptor | B | 8.9 | pIC50 | 1.26 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 511-514 |
| ChEMBL | Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type A receptor | B | 9.2 | pIC50 | 0.63 | nM | IC50 | J Med Chem (1996) 39: 5236-5245 [PMID:8978852] |
| ChEMBL | Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type A receptor stably expressed in CHO-K1 cells | B | 9.2 | pIC50 | 0.63 | nM | IC50 | J Med Chem (1996) 39: 562-569 [PMID:8558528] |
| ChEMBL | Displacement of CCK-8 from CHO cell membranes expressing human Cholecystokinin type A receptor | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (1995) 38: 207-211 [PMID:7837233] |
| ChEMBL | In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type A receptor expressed in CHO-K1 cells | B | 9.41 | pIC50 | 0.39 | nM | IC50 | J Med Chem (1995) 38: 3384-3390 [PMID:7650691] |
| ChEMBL | Displacement of radiolabeled CCK-8s from human CCK1 receptor | B | 9.43 | pIC50 | 0.37 | nM | IC50 | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | Displacement of [125I]CCK-8s from human recombinant CCK-A receptor expressed in CHO cells | B | 9.89 | pIC50 | 0.13 | nM | IC50 | Bioorg Med Chem (2016) 24: 1793-1810 [PMID:26988801] |
| ChEMBL | Displacement of [125I]CCK-8s from human recombinant CCK1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method | B | 9.89 | pIC50 | 0.13 | nM | IC50 | Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250] |
| ChEMBL | Displacement of [125I]-CCK-8 from human CCK1R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay | B | 9.95 | pIC50 | 0.11 | nM | IC50 | J Med Chem (2019) 62: 1407-1419 [PMID:30624060] |
| ChEMBL | Antagonist activity at CCK1 receptor expressed in HEK 293 cells assessed as accumulation of [3H]inositol phosphates by PI assay | F | 7.55 | pEC50 | 28.18 | nM | EC50 | J Med Chem (2006) 49: 2868-2875 [PMID:16686530] |
| ChEMBL | Antagonist activity at CCK1 receptor expressed in HEK 293 cells assessed as accumulation of [3H]inositol phosphates by PI assay | F | 7.55 | pEC50 | 28 | nM | EC50 | J Med Chem (2006) 49: 2868-2875 [PMID:16686530] |
| ChEMBL | Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type A receptor | B | 10 | pEC50 | 0.1 | nM | EC50 | J Med Chem (1995) 38: 3384-3390 [PMID:7650691] |
| ChEMBL | Agonist activity at human CCK1R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay | F | 10.36 | pEC50 | 0.04 | nM | EC50 | J Med Chem (2019) 62: 1407-1419 [PMID:30624060] |
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | Evaluated for binding affinity measured by inhibiting [3H]Boc[Nle28,31]CCK27-33 specific binding to Cholecystokinin receptor in rat pancreas membranes at a KD concentration of 4.4 nM | B | 8.06 | pKi | 8.71 | nM | Ki | J Med Chem (1987) 30: 962-968 [PMID:2438407] |
| ChEMBL | Inhibition of [3H]pCCK-8 specific binding to Cholecystokinin type A receptor of rat pancreas | B | 9.28 | pKi | 0.52 | nM | Ki | J Med Chem (1997) 40: 3402-3407 [PMID:9341915] |
| ChEMBL | Binding affinity for Cholecystokinin type A receptor using [125I]BH-CCK-8 in rat pancreatic tissue | B | 10.05 | pKi | 0.09 | nM | Ki | J Med Chem (1997) 40: 4302-4307 [PMID:9435899] |
| ChEMBL | Inhibition of [125I]BH-CCK-8 binding to Cholecystokinin type A receptor of rat pancreatic tissue | B | 10.05 | pKi | 0.09 | nM | Ki | J Med Chem (2000) 43: 2350-2355 [PMID:10882360] |
| GtoPdb | - | - | 7.2 | pIC50 | - | - | - | Proc Natl Acad Sci USA (1990) 87: 6728-32 [PMID:1975695] |
| ChEMBL | Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat pancreas membrane(CCK-A) | B | 8.97 | pIC50 | 1.08 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 855-860 |
| ChEMBL | Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type A receptor from rat pancreas | B | 8.98 | pIC50 | 1.04 | nM | IC50 | J Med Chem (1999) 42: 4659-4668 [PMID:10579828] |
| ChEMBL | Inhibition of [3H]pCCK-8 binding to cholecystokinin type A receptor of rat pancreas | B | 8.98 | pIC50 | 1.04 | nM | IC50 | J Med Chem (2001) 44: 4196-4206 [PMID:11708921] |
| ChEMBL | Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type A receptor of rat pancreas homogenates | B | 8.98 | pIC50 | 1.04 | nM | IC50 | J Med Chem (2004) 47: 5318-5329 [PMID:15456276] |
| ChEMBL | Compound was evaluated for the binding affinity towards rat pancreatic Cholecystokinin type A receptor | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1245-1248 [PMID:10866391] |
| ChEMBL | Displacement of 125I]-D-Tyr-Gly-[(Nle28,31)CCK-26-33] from rat cell membrane Cholecystokinin type A receptor | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 3127-3132 [PMID:9873689] |
| ChEMBL | Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini | B | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (1992) 35: 28-38 [PMID:1732532] |
| GtoPdb | - | - | 9.9 | pIC50 | - | - | - | Proc Natl Acad Sci USA (1990) 87: 6728-32 [PMID:1975695] |
| ChEMBL | Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type A receptor of rat pancreas | B | 10 | pIC50 | 0.1 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 889-894 |
| ChEMBL | Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to rat pancreas cholecystokinin type A receptor | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (1991) 34: 404-414 [PMID:1671419] |
| ChEMBL | Evaluated for inhibition of cholecystokinin type A receptor by displacing [125I]bolton hunter CCK-8 radioligand in the rat pancreas | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (1992) 35: 2573-2581 [PMID:1635058] |
| ChEMBL | Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type A receptor in the rat pancreas. | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (1993) 36: 552-565 [PMID:7684452] |
| Cholecystokinin A receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3501] [UniProtKB: Q63931] | ||||||||
| ChEMBL | Displacement of [3H]-pCCK-8 from cholecystokinin-A receptor in guinea pig pancreatic membrane | B | 9.15 | pKi | 0.7 | nM | Ki | J Med Chem (1993) 36: 166-172 [PMID:8421283] |
| ChEMBL | Compound was tested for binding affinity against CCK1 (cholecystokinin) receptor on guinea pig pancreatic membranes | B | 9.15 | pKi | 0.7 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| ChEMBL | The compound was tested for the inhibition of [3H]propionyl specific binding to CCK-8 receptor of guinea pig pancreatic membrane | B | 9.19 | pKi | 0.64 | nM | Ki | J Med Chem (1989) 32: 445-449 [PMID:2464062] |
| ChEMBL | Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type A receptor in pancreatic membranes of guinea-pig | B | 9.19 | pKi | 0.64 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 847-850 |
| ChEMBL | Displacement of 0.1 nM [3H]pCCK-8 from guinea pig pancreatic membranes | B | 9.19 | pKi | 0.64 | nM | Ki | J Med Chem (1989) 32: 1184-1190 [PMID:2724293] |
| ChEMBL | Ability to displace 1 nM [3H]pCCK-8 from Cholecystokinin type A receptor in guinea pig pancreatic membranes | B | 9.22 | pKi | 0.6 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 369-372 [PMID:14698161] |
| ChEMBL | Inhibition of [3H]pCCK-8 binding to Cholecystokinin type A receptor of Guinea pig pancreatic membranes | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (1997) 40: 647-658 [PMID:9057851] |
| ChEMBL | The compound was tested for the inhibition of [3H]propionyl specific binding to CCK-8 receptor of guinea pig brain | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (1989) 32: 445-449 [PMID:2464062] |
| ChEMBL | Displacement of [125I]BH-CCK-8 from Cholecystokinin type A receptor in guinea pig pancreas | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (1990) 33: 2950-2952 [PMID:1700123] |
| ChEMBL | Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig pancreas Cholecystokinin type A receptor | B | 9.55 | pIC50 | 0.28 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 855-860 |
| CCK2 receptor/Cholecystokinin B receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL298] [GtoPdb: 77] [UniProtKB: P32239] | ||||||||
| ChEMBL | The compound was evaluated for the inhibition of binding of [3H]-PD 140376 to Cholecystokinin type B receptor in guinea pig cortex. | B | 9.19 | pKi | 0.65 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 885-888 |
| ChEMBL | Inhibition of [3H]pCCK-8 binding to Guinea pig cortex membrane Cholecystokinin type B receptor | B | 9.19 | pKi | 0.64 | nM | Ki | J Med Chem (1997) 40: 647-658 [PMID:9057851] |
| ChEMBL | Displacement of radiolabeled CCK-8s from human CCK2 receptor | B | 9.43 | pKi | 0.37 | nM | Ki | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | Displacement of [3H]pCCK-8 from cholecystokinin type B receptor in guinea pig brain membrane | B | 9.52 | pKi | 0.3 | nM | Ki | J Med Chem (1993) 36: 166-172 [PMID:8421283] |
| ChEMBL | Binding affinity against cholecystokinin type B receptor on guinea pig cortex. | B | 9.52 | pKi | 0.3 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| ChEMBL | Inhibitory activity against Cholecystokinin type B receptor | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 799-802 |
| ChEMBL | Tested for the inhibition of [3H]pCCK-8 binding to Cholecystokinin type B receptor in guinea pig brain | B | 9.55 | pKi | 0.28 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 847-850 |
| ChEMBL | Displacement of 0.2 nM [3H]pCCK-8 from guinea pig brain membranes | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (1989) 32: 1184-1190 [PMID:2724293] |
| ChEMBL | Displacement of [125I]BH-CCK-8 from Cholecystokinin type B receptor of guinea pig cortex | B | 8.09 | pIC50 | 8.2 | nM | IC50 | J Med Chem (1990) 33: 2950-2952 [PMID:1700123] |
| ChEMBL | Displacement of [125I]Bolton-Hunter-CCK-8 from guinea pig cortex Cholecystokinin type B receptor | B | 8.8 | pIC50 | 1.6 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 855-860 |
| ChEMBL | Displacement of radiolabeled CCK-8s from human CCK2 receptor | B | 9.04 | pIC50 | 0.92 | nM | IC50 | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
| ChEMBL | Binding affinity against human Cholecystokinin type B receptor in CHO-K1 cells using [125I]-Bolton-Hunter CCK-8 as radioligand | B | 9.46 | pIC50 | 0.35 | nM | IC50 | J Med Chem (1996) 39: 3030-3034 [PMID:8709137] |
| ChEMBL | In vitro for binding affinity against human cholecystokinin type B receptor. | B | 9.46 | pIC50 | 0.35 | nM | IC50 | J Med Chem (1997) 40: 2706-2725 [PMID:9276016] |
| ChEMBL | Tested for 50% displacement of [125I]CCK-8 from membrane preparation isolated from CHO-K1 cells stably transfected with the cDNA of human Cholecystokinin type B receptor | B | 9.5 | pIC50 | 0.32 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 511-514 |
| ChEMBL | Compound was tested in vitro for its ability to displace [125I]Bolton-Hunter CCK-8 from membrane preparation isolated from CHO-KI cells stably transfected with cDNA of human Cholecystokinin type B receptor | B | 9.5 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1996) 39: 5236-5245 [PMID:8978852] |
| ChEMBL | Concentration required to displace [125I]Bolton-Hunter CCK-8 from human Cholecystokinin type B receptor stably expressed in CHO-K1 cells | B | 9.5 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1996) 39: 562-569 [PMID:8558528] |
| ChEMBL | Displacement of CCK-8 from human Cholecystokinin type B receptor expressing CHO cell membranes | B | 9.5 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1995) 38: 207-211 [PMID:7837233] |
| ChEMBL | In vitro displacement of [125I]BH-CCK-8 from cDNA of human Cholecystokinin type B receptor expressed in CHO-K1 cells | B | 9.5 | pIC50 | 0.32 | nM | IC50 | J Med Chem (1995) 38: 3384-3390 [PMID:7650691] |
| ChEMBL | Displacement of [125I]-CCK-8 from human CCK2R expressed in human 1321N1 cell membranes after 2 hrs by SPA assay | B | 9.54 | pIC50 | 0.29 | nM | IC50 | J Med Chem (2019) 62: 1407-1419 [PMID:30624060] |
| ChEMBL | Binding affinity against human Cholecystokinin type B receptor by displacement of [125I]CCK-8 | B | 9.64 | pIC50 | 0.23 | nM | IC50 | J Med Chem (1996) 39: 2655-2658 [PMID:8709093] |
| ChEMBL | Displacement of [125I]CCK-8s from human recombinant CCK-B receptor expressed in CHO cells | B | 9.92 | pIC50 | 0.12 | nM | IC50 | Bioorg Med Chem (2016) 24: 1793-1810 [PMID:26988801] |
| ChEMBL | Displacement of [125I]CCK-8s from human recombinant CCK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method | B | 9.92 | pIC50 | 0.12 | nM | IC50 | Bioorg Med Chem (2017) 25: 471-482 [PMID:27876250] |
| GtoPdb | - | - | 10 | pIC50 | - | - | - |
J Biol Chem (1993) 268: 8164-9 [PMID:7681836]; J Biol Chem (1993) 268: 18300-5 [PMID:8349705] |
| ChEMBL | Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay | F | 7.57 | pEC50 | 27 | nM | EC50 | J Med Chem (2006) 49: 2868-2875 [PMID:16686530] |
| ChEMBL | Antagonist activity at CCK2 receptor expressed in HEK293 cells assessed as accumulation of [3H]inositol phosphates by PI assay | F | 7.57 | pEC50 | 26.92 | nM | EC50 | J Med Chem (2006) 49: 2868-2875 [PMID:16686530] |
| ChEMBL | Agonist activity at human CCK2R expressed in human 1321N1 cells assessed as IP1 accumulation after 1 hr by HTRF assay | F | 9.3 | pEC50 | 0.5 | nM | EC50 | J Med Chem (2019) 62: 1407-1419 [PMID:30624060] |
| ChEMBL | Displacement of [125I]CCK-8 from CCK2 receptor in human FGS7 Jurkat cells | B | 10.03 | pEC50 | 0.09 | nM | EC50 | J Nat Prod (2006) 69: 432-435 [PMID:16562853] |
| ChEMBL | Compound was evaluated for the [Ca2+] mobilization innstably transfected CHO-K1 cell lines expressing human Cholecystokinin type B receptor | B | 10.3 | pEC50 | 0.05 | nM | EC50 | J Med Chem (1995) 38: 3384-3390 [PMID:7650691] |
| CCK2 receptor/Cholecystokinin B receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2854] [GtoPdb: 77] [UniProtKB: P56481] | ||||||||
| ChEMBL | In vitro binding affinity against Cholecystokinin type B receptor in mouse cerebral cortical membranes using [125I]Tyr(SO3H)27]-CCK-8 binding assay | B | 8.89 | pIC50 | 1.3 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 705-709 [PMID:11266174] |
| ChEMBL | Evaluated for inhibition of cholecystokinin type B receptor by displacing [125I]-Bolton hunter CCK-8 radioligand in the mouse cerebral cortex | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Med Chem (1992) 35: 2573-2581 [PMID:1635058] |
| ChEMBL | Inhibition of binding of [125I]Bolton-Hunter labeled CCK-8 to cholecystokinin type B receptor in the mouse cerebral cortex | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Med Chem (1993) 36: 552-565 [PMID:7684452] |
| ChEMBL | Binding affinity towards Cholecystokinin type B receptor in mouse cortex membrane | B | 9.52 | pIC50 | 0.3 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1245-1248 [PMID:10866391] |
| ChEMBL | Half-maximal inhibition of specific binding of [125I]bolton hunter CCK-8 to mouse cerebral cortex cholecystokinin type B receptor | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Med Chem (1991) 34: 404-414 [PMID:1671419] |
| ChEMBL | Inhibition of [125I]- Bolton-Hunter CCK-26-33 binding to Cholecystokinin type B receptor of mouse cerebral cortex | B | 9.52 | pIC50 | 0.3 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 889-894 |
| CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| ChEMBL | Inhibition of [3H]- pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex membranes | B | 8.55 | pKi | 2.8 | nM | Ki | J Med Chem (1997) 40: 3402-3407 [PMID:9341915] |
| ChEMBL | Ability to displace 1 nM [3H]pCCK-8 from rat Cholecystokinin type B receptor stably expressing in CHO cells | B | 9.15 | pKi | 0.7 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 369-372 [PMID:14698161] |
| ChEMBL | Affinity to inhibit [3H]pCCK-8 specific binding on rat brain Cholecystokinin type B receptor expressed in CHO cells | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (1997) 40: 647-658 [PMID:9057851] |
| ChEMBL | Compound was tested for binding affinity against Cholecystokinin type B receptor expressed in CHO cells on the rat brain. | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
| ChEMBL | Binding affinity for Cholecystokinin type B receptor using [125I]-BH-CCK-8 in rat cortex synaptosomes | B | 9.39 | pKi | 0.41 | nM | Ki | J Med Chem (1997) 40: 4302-4307 [PMID:9435899] |
| ChEMBL | Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand | B | 9.39 | pKi | 0.41 | nM | Ki | J Med Chem (2000) 43: 2350-2355 [PMID:10882360] |
| ChEMBL | Tested for the inhibition of specific [3H]propionyl-CCK-8 binding to rat cerebral cortex membrane(CCK-B) | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 855-860 |
| ChEMBL | Binding affinity by competitive inhibition of the radioligand [3H]pCCK-8 at Cholecystokinin type B receptor from rat cerebral cortex membrane | B | 8.25 | pIC50 | 5.6 | nM | IC50 | J Med Chem (1999) 42: 4659-4668 [PMID:10579828] |
| ChEMBL | Inhibition of [3H]pCCK-8 binding to cholecystokinin type B receptor of rat cerebral cortex | B | 8.25 | pIC50 | 5.6 | nM | IC50 | J Med Chem (2001) 44: 4196-4206 [PMID:11708921] |
| ChEMBL | Inhibition of [3H]-pCCK-8 binding to Cholecystokinin type B receptor of rat cerebral cortex homogenates | B | 8.25 | pIC50 | 5.6 | nM | IC50 | J Med Chem (2004) 47: 5318-5329 [PMID:15456276] |
| ChEMBL | Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1992) 35: 28-38 [PMID:1732532] |
| ChEMBL | Effective concentration for the stimulation of Inositol Phosphate accumulation in CHO cells expressing wild-type Cholecystokinin type B receptor | F | 9.2 | pEC50 | 0.63 | nM | EC50 | J Med Chem (1997) 40: 647-658 [PMID:9057851] |
| ChEMBL | Affinity against Cholecystokinin type B receptor expressed in CHO cells on rat brain. | F | 9.2 | pEC50 | 0.63 | nM | EC50 | J Med Chem (2000) 43: 3614-3623 [PMID:11020275] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
