eplerenone [Ligand Id: 2876] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1095097 (Eplerenone, Inspra, SC-66110, SC-6611O) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| ChEMBL | Antagonist activity at androgen receptor (unknown origin) by NH Pro assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Antagonist activity at androgen receptor | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Displacement of [3H]testosterone from AR | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2011) 54: 8616-8631 [PMID:22074142] |
| ChEMBL | Displacement of [3H]testosterone from androgen receptor (unknown origin) expressed in 293 cells after 16 hrs by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2014) 22: 5428-5445 [PMID:25187277] |
| ChEMBL | Agonist activity at androgen receptor (unknown origin) by NH Pro assay | B | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] | ||||||||
| ChEMBL | Antagonist activity at estrogen receptor alpha (unknown origin) by NH Pro assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Antagonist activity at estrogen receptor | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Agonist activity at estrogen receptor alpha (unknown origin) by NH Pro assay | B | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] | ||||||||
| ChEMBL | Antagonist activity at estrogen receptor beta (unknown origin) by NH Pro assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Agonist activity at estrogen receptor beta (unknown origin) by NH Pro assay | B | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] | ||||||||
| ChEMBL | Binding affinity to recombinant human GR LBD by fluormone GS red-fluorescence polarization assay | B | 5.5 | pKi | 3162.28 | nM | Ki | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| ChEMBL | Antagonist activity at glucocorticoid receptor (unknown origin) by NH Pro assay | B | 4.74 | pIC50 | 18000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Displacement of [3H]dexomethasone from GR | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2011) 54: 8616-8631 [PMID:22074142] |
| ChEMBL | Antagonist activity at glucocorticoid receptor | F | 5.05 | pIC50 | >8940 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Agonist activity at glucocorticoid receptor (unknown origin) by NH Pro assay | B | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235] | ||||||||
| ChEMBL | Displacement of [3H]-aldosterone to human mineralocorticoid receptor LBD by radiometric binding assay | B | 6.9 | pKi | 125.89 | nM | Ki | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| GtoPdb | - | - | 6.91 | pKi | 124 | nM | Ki | J Med Chem (2007) 50: 6443-5 [PMID:18038968] |
| ChEMBL | Displacement of [3H]aldosterone from cytosolic human MR expressed in HEK293 cells after 16 hrs by scintillation counting | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Med Chem (2011) 54: 8616-8631 [PMID:22074142] |
| ChEMBL | Displacement of [3H]aldosterone from human mineralocorticoid receptor expressed in 293 cells after 16 hrs by scintillation counting | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem (2014) 22: 5428-5445 [PMID:25187277] |
| ChEMBL | Antagonist activity at human MR transfected in human COS1 cells after 1 day by luciferase reporter gene assay | F | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (2011) 54: 8616-8631 [PMID:22074142] |
| ChEMBL | Antagonist activity at human mineralocorticoid receptor expressed in COS1 cells after 1 day by luciferase reporter gene assay | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2014) 22: 5428-5445 [PMID:25187277] |
| ChEMBL | Antagonist activity at gal4-fused human mineralocorticoid receptor LBD expressed in UAS-MR-bla HEK293 cells by luciferase reporter gene assay | B | 6.1 | pIC50 | 794.33 | nM | IC50 | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| ChEMBL | Antagonist activity at full length human mineralocorticoid receptor expressed in human U2OS cells by luciferase reporter gene assay | B | 6.4 | pIC50 | 398.11 | nM | IC50 | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| ChEMBL | Antagonist activity at human full-length MCR assessed as inhibition of receptor binding to co-activator peptide by PathHunter assay | B | 6.61 | pIC50 | 244 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2866-2869 [PMID:27161805] |
| ChEMBL | Antagonist activity at mineralocorticoid receptor (unknown origin) by PathHunter assay | B | 6.61 | pIC50 | 244 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1681-1684 [PMID:24630411] |
| ChEMBL | Antagonist activity at human mineralocorticoid receptor assessed as inhibition of binding to coactivator peptide by NH Pro assay | B | 6.62 | pIC50 | 240 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Antagonist activity at Gal4-fused mineralocorticoid receptor expressed in human HuH7 cells assessed as inhibition of aldosterone-induced receptor activation by luciferase reporter gene assay | F | 6.87 | pIC50 | 135 | nM | IC50 | J Med Chem (2010) 53: 4300-4304 [PMID:20408553] |
| ChEMBL | Antagonist activity at mineralocorticoid receptor (unknown origin) by Gal4-based cellular assay | B | 6.91 | pIC50 | 122 | nM | IC50 | J Med Chem (2014) 57: 4273-4288 [PMID:24738581] |
| ChEMBL | Antagonist activity at Gal4-tagged mineralocorticoid receptor expressed in human Huh7 cells by luciferase reporter gene assay | F | 6.91 | pIC50 | 122 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Antagonist activity at mineralocorticoid receptor LBD expressed in human HUH7 cells coexpressing GAL4 by luciferase reporter gene assay | F | 6.91 | pIC50 | 122 | nM | IC50 | J Med Chem (2010) 53: 5970-5978 [PMID:20672820] |
| ChEMBL | Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as blocking of nuclear translocation of mineralocorticoid receptor in presence of aldosterone by receptor translocation assay | B | 7.2 | pIC50 | 63.1 | nM | IC50 | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| ChEMBL | Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid receptor in absence of aldosterone by receptor translocation assay | B | 7 | pEC50 | 100 | nM | EC50 | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| Mineralocorticoid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3507] [GtoPdb: 626] [UniProtKB: P22199] | ||||||||
| ChEMBL | Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assay | B | 7.4 | pIC50 | 39.81 | nM | IC50 | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] | ||||||||
| ChEMBL | Binding affinity to recombinant human progesterone receptor LBD by fluormone PL red-fluorescence polarization assay | B | 4.7 | pKi | 19952.62 | nM | Ki | J Med Chem (2019) 62: 1385-1406 [PMID:30596500] |
| ChEMBL | Antagonist activity at progesterone receptor beta (unknown origin) by NH Pro assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
| ChEMBL | Antagonist activity at progesterone receptor | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2010) 53: 5979-6002 [PMID:20672822] |
| ChEMBL | Displacement of [3H]progesterone from PR | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2011) 54: 8616-8631 [PMID:22074142] |
| ChEMBL | Displacement of [[3H]-Progesterone from progesterone receptor (unknown origin) expressed in 293 cells after 16 hrs by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2014) 22: 5428-5445 [PMID:25187277] |
| ChEMBL | Displacement of [3H]-Dexamethasone from glucocorticoid receptor (unknown origin) expressed in 293 cells after 16 hrs by scintillation counting | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem (2014) 22: 5428-5445 [PMID:25187277] |
| ChEMBL | Agonist activity at progesterone receptor beta (unknown origin) by NH Pro assay | B | 4.7 | pEC50 | >20000 | nM | EC50 | Bioorg Med Chem Lett (2013) 23: 4388-4392 [PMID:23777778] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
