ChEMBL ligand: CHEMBL38576 (ICI-199441)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor/Kappa opioid receptor in Mouse [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] Mu opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!
UT receptor/Urotensin II receptor in Human [ChEMBL: CHEMBL3764] [GtoPdb: 365] [UniProtKB: Q9UKP6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Inhibitory constant against human Opioid receptor delta 1 using [3H]diprenorphine as radio ligand	B	7.62	pKi	24	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2647-2652 [PMID:15863335]
ChEMBL	Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO-K1 cells	B	7.62	pKi	24	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3667-3671 [PMID:18487043]
ChEMBL	Tested for inhibitory concentration against [3H]DPDPE binding at sites of delta-opioid receptor in guinea pig brain membrane	B	6.22	pIC50	600	nM	IC50	J Med Chem (1994) 37: 2856-2864 [PMID:8071934]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	In vitro binding affinity towards Opioid receptor kappa 1 by displacement of bound [3H]U-69593	B	10.27	pKi	0.05	nM	Ki	Bioorg Med Chem Lett (2000) 10: 2567-2570 [PMID:11086731]
ChEMBL	Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO-K1 cells	B	10.36	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3667-3671 [PMID:18487043]
ChEMBL	In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligand	B	10.37	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1279-1282 [PMID:15713370]
ChEMBL	Inhibitory constant against human Opioid receptor kappa using [3H]diprenorphine as radio ligand	B	10.4	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2647-2652 [PMID:15863335]
GtoPdb	Displacement of [3H]diprenorphine from human κ opioid receptor	-	10.4	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1279-82 [PMID:15713370]
ChEMBL	Agonist activity at kappa opioid receptor	F	9.4	pEC50	0.4	nM	EC50	Bioorg Med Chem Lett (2008) 18: 3716-3719 [PMID:18524591]
ChEMBL	Agonist activity assessed by ability to stimulate [35S]GTP gammaS binding to opioid receptor kappa in human membranes	F	9.52	pEC50	0.3	nM	EC50	Bioorg Med Chem Lett (2005) 15: 2647-2652 [PMID:15863335]
ChEMBL	Agonist activity at human kappa opioid receptor transfected in CHO cells by [35S]GTP-gamma-S binding assay	F	9.52	pEC50	0.3	nM	EC50	Bioorg Med Chem Lett (2008) 18: 3667-3671 [PMID:18487043]
κ receptor/Kappa opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4329] [GtoPdb: 318] [UniProtKB: P33534]
ChEMBL	Inhibitory activity against Opioid receptor kappa 1 in electrically stimulated mouse vas deferens (MVD) preparation.	B	8.6	pIC50	2.5	nM	IC50	J Med Chem (1996) 39: 1729-1735 [PMID:8648612]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Binding affinity against opioid receptor kappa, in guinea pig brain membrane, using [3H]bremazocine as the radioligand.	B	8.16	pIC50	6.9	nM	IC50	J Med Chem (1991) 34: 3149-3158 [PMID:1659636]
ChEMBL	Compound was evaluated for the Opioid receptor kappa 1 affinity using guinea pig brain membranes.	B	8.16	pIC50	6.9	nM	IC50	J Med Chem (1991) 34: 181-189 [PMID:1846918]
ChEMBL	Tested for inhibitory concentration against [3H]U-69593 binding at sites of kappa-opioid receptor in guinea pig brain membrane	B	8.82	pIC50	1.5	nM	IC50	J Med Chem (1994) 37: 2856-2864 [PMID:8071934]
ChEMBL	Inhibitory activity against Opioid receptor kappa 1 in electrically stimulated guinea pig longitudinal ileal muscle (GPI) preparation.	B	9.57	pIC50	0.27	nM	IC50	J Med Chem (1996) 39: 1729-1735 [PMID:8648612]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Inhibitory constant against human Opioid receptor mu 1 using [3H]diprenorphine as radio ligand	B	7.28	pKi	53	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2647-2652 [PMID:15863335]
ChEMBL	Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO-K1 cells	B	7.28	pKi	53	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3667-3671 [PMID:18487043]
GtoPdb	Displacement of [3H]diprenorphine from human μ opioid receptor expressed in CHO-K1 cells	-	7.28	pKi	53	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3667-71 [PMID:18487043]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL	Tested for inhibitory concentration against [3H]DAMGO binding at sites of mu-opioid receptor in guinea pig brain membrane	B	6.82	pIC50	150	nM	IC50	J Med Chem (1994) 37: 2856-2864 [PMID:8071934]
UT receptor/Urotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3764] [GtoPdb: 365] [UniProtKB: Q9UKP6]
ChEMBL	Binding affinity to human urotensin-2 receptor	B	5.4	pKi	4000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3716-3719 [PMID:18524591]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]