theophylline [Ligand Id: 413] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL190 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ATPase family AAA domain containing 2/ATPase family AAA domain-containing protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2150837] [GtoPdb: 2719] [UniProtKB: Q6PL18] | ||||||||
| ChEMBL | Inhibition of recombinant ATAD2 bromodomain (unknown origin) by TR-FRET assay | B | 3.49 | pIC50 | 320000 | nM | IC50 | J Med Chem (2025) 68: 986-1001 [PMID:39761118] |
| A1 receptor in Human [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| GtoPdb | - | - | 5.2 | pKi | - | - | - |
J Biol Chem (1994) 269: 32077-84 [PMID:7798201]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]; Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]; Biochem Pharmacol (2001) 62: 1163-73 [PMID:11705449] |
| A1 receptor in Rat [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| GtoPdb | - | - | 5.06 | pKi | 8740 | nM | Ki |
Drug Dev Res (1999) : 45-53; J Med Chem (1993) 36: 3341-9 [PMID:8230124] |
| A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| GtoPdb | - | - | 5.8 | pKi | - | - | - |
Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]; Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]; Br J Pharmacol (1997) 121: 353-60 [PMID:9179373]; Drug Dev Res (1999) : 45-53 |
| A2A receptor in Rat [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
| GtoPdb | - | - | 4.66 | pKi | 22000 | nM | Ki |
Drug Dev Res (1999) : 45-53; J Med Chem (1993) 36: 3341-9 [PMID:8230124] |
| A2B receptor in Human [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| GtoPdb | - | - | 5.04 | pKi | 9070 | nM | Ki |
Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]; Biochem Pharmacol (2001) 62: 1163-73 [PMID:11705449]; J Med Chem (2002) 45: 2131-8 [PMID:12014951]; Purinergic Signal (2006) 2: 559-71 [PMID:18404493] |
| A2B receptor in Mouse [GtoPdb: 20] [UniProtKB: Q60614] | ||||||||
| GtoPdb | - | - | 5.25 | pKi | 5630 | nM | Ki | J Pharmacol Exp Ther (2009) 329: 2-13 [PMID:19141710] |
| A3 receptor in Human [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| GtoPdb | - | - | 4.65 | pKi | 22300 | nM | Ki |
Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]; Drug Dev Res (1999) : 45-53 |
| A3 receptor in Rat [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
| GtoPdb | - | - | 4.07 | pKi | 85000 | nM | Ki |
Mol Pharmacol (1994) 45: 1101-11 [PMID:8022403]; Bioconjug Chem (1995) 6: 255-63 [PMID:7632796] |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
