SB 207710 [Ligand Id: 257] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL114112
  • 5-HT4 receptor/5-hydroxytryptamine receptor 4 in Human [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
  • 5-HT4 receptor/5-hydroxytryptamine receptor 4 in Rat [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758]
  • 5-hydroxytryptamine receptor 4 in Guinea pig [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
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  • 5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT4 receptor/5-hydroxytryptamine receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639]
ChEMBL Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cells B 8.66 pKi 2.2 nM Ki J Med Chem (2010) 53: 7035-7047 [PMID:20812727]
GtoPdb - - 10.3 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2001) 363: 146-60 [PMID:11218067]
ChEMBL Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assay F 7.9 pEC50 12.59 nM EC50 J Med Chem (2010) 53: 7035-7047 [PMID:20812727]
5-HT4 receptor/5-hydroxytryptamine receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758]
ChEMBL Binding affinity to 5HT4 receptor in rat striatal membranes B 9.52 pKd 0.3 nM Kd Bioorg Med Chem Lett (2013) 23: 6243-6247 [PMID:24157369]
5-hydroxytryptamine receptor 4 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528]
ChEMBL Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes B 9.7 pKi 0.2 nM Ki J Med Chem (2010) 53: 7035-7047 [PMID:20812727]
Serotonin 4 (5-HT4) receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2696] [UniProtKB: Q6Q253]
ChEMBL Binding affinity to 5HT4 receptor in pig striatal membranes B 10.1 pKd 0.08 nM Kd Bioorg Med Chem Lett (2013) 23: 6243-6247 [PMID:24157369]
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969]
GtoPdb - - 5.5 pKi - - - Naunyn Schmiedebergs Arch Pharmacol (2001) 363: 620-32 [PMID:11414657]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]