SB 207710 [Ligand Id: 257] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL114112 (SB-207710) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1875] [GtoPdb: 9] [UniProtKB: Q13639] | ||||||||
| ChEMBL | Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cells | B | 8.66 | pKi | 2.2 | nM | Ki | J Med Chem (2010) 53: 7035-7047 [PMID:20812727] |
| GtoPdb | - | - | 10.3 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2001) 363: 146-60 [PMID:11218067] |
| ChEMBL | Agonist activity at 5HT4 receptor expressed in HEK293/L9 cells by cAMP assay | F | 7.9 | pEC50 | 12.59 | nM | EC50 | J Med Chem (2010) 53: 7035-7047 [PMID:20812727] |
| Serotonin 4 (5-HT4) receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2696] [UniProtKB: Q6Q253] | ||||||||
| ChEMBL | Binding affinity to 5HT4 receptor in pig striatal membranes | B | 10.1 | pKd | 0.08 | nM | Kd | Bioorg Med Chem Lett (2013) 23: 6243-6247 [PMID:24157369] |
| 5-HT4 receptor/Serotonin 4 (5-HT4) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4317] [GtoPdb: 9] [UniProtKB: Q62758] | ||||||||
| ChEMBL | Binding affinity to 5HT4 receptor in rat striatal membranes | B | 9.52 | pKd | 0.3 | nM | Kd | Bioorg Med Chem Lett (2013) 23: 6243-6247 [PMID:24157369] |
| Serotonin 4 (5-HT4) receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5017] [UniProtKB: O70528] | ||||||||
| ChEMBL | Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranes | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (2010) 53: 7035-7047 [PMID:20812727] |
| 5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
| GtoPdb | - | - | 5.5 | pKi | - | - | - | Naunyn Schmiedebergs Arch Pharmacol (2001) 363: 620-32 [PMID:11414657] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
