compound 1a [PMID: 17556356] [Ligand Id: 2833] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL478524 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Estrogen-related receptor-α/Estrogen-related receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3429] [GtoPdb: 622] [UniProtKB: P11474] | ||||||||
| GtoPdb | - | - | 6.7 | pIC50 | - | - | - | J Biol Chem (2007) 282: 23231-9 [PMID:17556356] |
| ChEMBL | Binding affinity to ERRalpha ligand binding domain by FRET assay | B | 6.72 | pIC50 | 190 | nM | IC50 | J Biol Chem (2007) 282: 23231-23239 [PMID:17556356] |
| ChEMBL | Antagonist activity at 6his-tagged ERRalpha LBD assessed as inhibition of recruitment of GST-labeled coactivator Scr2 by TR-FRET assay | F | 6.72 | pIC50 | 190 | nM | IC50 | J Med Chem (2011) 54: 788-808 [PMID:21218783] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
