dATP [Ligand Id: 1760] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL335538 (2'-Deoxyadenosine 5'-Triphosphate, dATP, Deoxyadenosine 5'-Triphosphate)
  • Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
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  • P2Y11 receptor/Purinergic receptor P2Y11 in Human [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL Binding affinity to HIV1 wild type reverse transcriptase p66/p51 expressed in Escherichia coli assessed as incorporation of drug to DNA by gel electrophoresis B 5.12 pKd 7500 nM Kd Antimicrob. Agents Chemother. (2007) 51: 3162-3167 [PMID:17620380]
ChEMBL Binding affinity to HIV1 recombinant reverse transcriptase p66/p51 K65R mutant expressed in Escherichia coli assessed as incorporation of drug to DNA by gel electrophoresis B 5.16 pKd 6900 nM Kd Antimicrob. Agents Chemother. (2007) 51: 3162-3167 [PMID:17620380]
ChEMBL Binding affinity to HIV1 reverse transcriptase K65R mutant by pre-steady state kinetics study B 5.18 pKd 6600 nM Kd Bioorg. Med. Chem. Lett. (2012) 22: 4064-4067 [PMID:22595174]
ChEMBL Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics study B 5.34 pKd 4600 nM Kd Bioorg. Med. Chem. Lett. (2012) 22: 4064-4067 [PMID:22595174]
ChEMBL Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNA B 5.49 pKd 3200 nM Kd Eur. J. Med. Chem. (2011) 46: 3832-3844 [PMID:21700368]
ChEMBL Binding affinity to HIV1 reverse transcriptase B 5.49 pKd 3200 nM Kd Antimicrob. Agents Chemother. (2009) 53: 3715-3719 [PMID:19596885]
ChEMBL Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNA B 5.6 pKd 2500 nM Kd Eur. J. Med. Chem. (2011) 46: 3832-3844 [PMID:21700368]
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652]
ChEMBL Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes F 4.72 pEC50 19000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]
P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91]
GtoPdb - - 5 pEC50 - - - Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132]
ChEMBL Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) F 5.05 pEC50 9000 nM EC50 J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]