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ChEMBL ligand: CHEMBL335538 (2'-Deoxyadenosine 5'-Triphosphate, dATP, Deoxyadenosine 5'-Triphosphate) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
ChEMBL | Binding affinity to HIV1 wild type reverse transcriptase p66/p51 expressed in Escherichia coli assessed as incorporation of drug to DNA by gel electrophoresis | B | 5.12 | pKd | 7500 | nM | Kd | Antimicrob. Agents Chemother. (2007) 51: 3162-3167 [PMID:17620380] |
ChEMBL | Binding affinity to HIV1 recombinant reverse transcriptase p66/p51 K65R mutant expressed in Escherichia coli assessed as incorporation of drug to DNA by gel electrophoresis | B | 5.16 | pKd | 6900 | nM | Kd | Antimicrob. Agents Chemother. (2007) 51: 3162-3167 [PMID:17620380] |
ChEMBL | Binding affinity to HIV1 reverse transcriptase K65R mutant by pre-steady state kinetics study | B | 5.18 | pKd | 6600 | nM | Kd | Bioorg. Med. Chem. Lett. (2012) 22: 4064-4067 [PMID:22595174] |
ChEMBL | Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics study | B | 5.34 | pKd | 4600 | nM | Kd | Bioorg. Med. Chem. Lett. (2012) 22: 4064-4067 [PMID:22595174] |
ChEMBL | Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNA | B | 5.49 | pKd | 3200 | nM | Kd | Eur. J. Med. Chem. (2011) 46: 3832-3844 [PMID:21700368] |
ChEMBL | Binding affinity to HIV1 reverse transcriptase | B | 5.49 | pKd | 3200 | nM | Kd | Antimicrob. Agents Chemother. (2009) 53: 3715-3719 [PMID:19596885] |
ChEMBL | Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNA | B | 5.6 | pKd | 2500 | nM | Kd | Eur. J. Med. Chem. (2011) 46: 3832-3844 [PMID:21700368] |
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652] | ||||||||
ChEMBL | Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes | F | 4.72 | pEC50 | 19000 | nM | EC50 | J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051] |
P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91] | ||||||||
GtoPdb | - | - | 5 | pEC50 | - | - | - | Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132] |
ChEMBL | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) | F | 5.05 | pEC50 | 9000 | nM | EC50 | J. Med. Chem. (2002) 45: 4057-4093 [PMID:12213051] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]