Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL335538 (2'-Deoxyadenosine 5'-Triphosphate, dATP, Deoxyadenosine 5'-Triphosphate) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
ChEMBL | Binding affinity to HIV1 wild type reverse transcriptase p66/p51 expressed in Escherichia coli assessed as incorporation of drug to DNA by gel electrophoresis | B | 5.12 | pKd | 7500 | nM | Kd | Antimicrob Agents Chemother (2007) 51: 3162-3167 [PMID:17620380] |
ChEMBL | Binding affinity to HIV1 recombinant reverse transcriptase p66/p51 K65R mutant expressed in Escherichia coli assessed as incorporation of drug to DNA by gel electrophoresis | B | 5.16 | pKd | 6900 | nM | Kd | Antimicrob Agents Chemother (2007) 51: 3162-3167 [PMID:17620380] |
ChEMBL | Binding affinity to HIV1 reverse transcriptase K65R mutant by pre-steady state kinetics study | B | 5.18 | pKd | 6600 | nM | Kd | Bioorg Med Chem Lett (2012) 22: 4064-4067 [PMID:22595174] |
ChEMBL | Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics study | B | 5.34 | pKd | 4600 | nM | Kd | Bioorg Med Chem Lett (2012) 22: 4064-4067 [PMID:22595174] |
ChEMBL | Binding affinity to HIV1 reverse transcriptase assessed as L-3'-azido-NTP incorporation in nascent DNA | B | 5.49 | pKd | 3200 | nM | Kd | Eur J Med Chem (2011) 46: 3832-3844 [PMID:21700368] |
ChEMBL | Binding affinity to HIV1 reverse transcriptase | B | 5.49 | pKd | 3200 | nM | Kd | Antimicrob Agents Chemother (2009) 53: 3715-3719 [PMID:19596885] |
ChEMBL | Binding affinity to HIV1 reverse transcriptase M184V mutant assessed as L-3'-azido-NTP incorporation in nascent DNA | B | 5.6 | pKd | 2500 | nM | Kd | Eur J Med Chem (2011) 46: 3832-3844 [PMID:21700368] |
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652] | ||||||||
ChEMBL | Evaluated for agonist activity against phospholipase C coupled P2Y purinoceptor 1 (P2Y1) of turkey erythrocytes | F | 4.72 | pEC50 | 19000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
P2Y11 receptor/Purinergic receptor P2Y11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4867] [GtoPdb: 327] [UniProtKB: Q96G91] | ||||||||
GtoPdb | - | - | 5 | pEC50 | - | - | - | Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132] |
ChEMBL | Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11) | F | 5.05 | pEC50 | 9000 | nM | EC50 | J Med Chem (2002) 45: 4057-4093 [PMID:12213051] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]