BX 471 [Ligand Id: 767] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL232656 (BX-471, BX-741)
  • CCR1/C-C chemokine receptor type 1 in Human [ChEMBL: CHEMBL2413] [GtoPdb: 58] [UniProtKB: P32246]
  • CCR1/C-C chemokine receptor type 1 in Mouse [ChEMBL: CHEMBL3872] [GtoPdb: 58] [UniProtKB: P51675]
  • CCR1/C-C chemokine receptor type 1 in Rat [ChEMBL: CHEMBL5499] [GtoPdb: 58] [UniProtKB: Q9JLY8]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCR1/C-C chemokine receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2413] [GtoPdb: 58] [UniProtKB: P32246]
ChEMBL Binding affinity to human CCR1 by radioligand binding assay B 9 pKd 1 nM Kd J. Med. Chem. (2012) 55: 9363-9392 [PMID:22931505]
GtoPdb - - 9 pKi 1 nM Ki J. Biol. Chem. (2000) 275: 19000-8 [PMID:10748002]
ChEMBL Binding affinity to CCR1 B 9 pKi 1 nM Ki J. Med. Chem. (2012) 55: 9363-9392 [PMID:22931505]
ChEMBL Binding Affinity at CCL3 B 7.51 pIC50 31 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 3109-3112 [PMID:17383873]
ChEMBL Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis F 7.74 pIC50 18 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 3367-3372 [PMID:17446072]
ChEMBL Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR F 7.74 pIC50 18 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 3367-3372 [PMID:17446072]
ChEMBL Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells B 8.26 pIC50 5.5 nM IC50 J. Med. Chem. (2009) 52: 1295-1301 [PMID:19183043]
ChEMBL Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs F 8.82 pIC50 1.5 nM IC50 J. Med. Chem. (2009) 52: 1295-1301 [PMID:19183043]
CCR1/C-C chemokine receptor type 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3872] [GtoPdb: 58] [UniProtKB: P51675]
ChEMBL Binding affinity to mouse CCR1 by radioligand binding assay B 6.7 pKd 200 nM Kd J. Med. Chem. (2012) 55: 9363-9392 [PMID:22931505]
ChEMBL Binding affinity at mouse CCR1 B 6.21 pIC50 615 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 3367-3372 [PMID:17446072]
CCR1/C-C chemokine receptor type 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5499] [GtoPdb: 58] [UniProtKB: Q9JLY8]
ChEMBL Binding affinity at rat CCR1 B 7.23 pIC50 59 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 3367-3372 [PMID:17446072]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]