ChEMBL ligand: CHEMBL727 (Lanvis, NSC-752, NSC-76504, Tabloid, Thioguanine, Thioguanine anhydrous, Thioguanine, anhydrous, Thioguanine hemihydrate, Tioguanina, Tioguanine, Tioguanine hemihydrate)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase in Escherichia coli [ChEMBL: CHEMBL3217379] [UniProtKB: P26281] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] There should be some charts here, you may need to enable JavaScript!
Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530] There should be some charts here, you may need to enable JavaScript!
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
Tyrosinase in Agaricus bisporus [ChEMBL: CHEMBL3318] [UniProtKB: O42713] There should be some charts here, you may need to enable JavaScript!
ubiquitin specific peptidase 2/Ubiquitin carboxyl-terminal hydrolase 2 in Human [ChEMBL: CHEMBL1293227] [GtoPdb: 2430] [UniProtKB: O75604] There should be some charts here, you may need to enable JavaScript!
xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3217379] [UniProtKB: P26281]
ChEMBL	Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR assay based alternative equilibrium affinity method in presence of AMP-CPP	B	4.74	pKd	18000	nM	Kd	Bioorg Med Chem (2014) 22: 2157-2165 [PMID:24613625]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL	DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)	B	4.91	pKi	12258	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)	B	4.66	pIC50	21687	nM	IC50	DrugMatrix in vitro pharmacology data
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL	DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid)	B	4.79	pIC50	16159	nM	IC50	DrugMatrix in vitro pharmacology data
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)	B	6.22	pIC50	601	nM	IC50	DrugMatrix in vitro pharmacology data
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL	DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein)	B	5.26	pIC50	5516	nM	IC50	DrugMatrix in vitro pharmacology data
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Inhibition of [3H]hypoxanthine uptake in Plasmodium falciparum 3D7	F	4.67	pIC50	21300	nM	IC50	J Med Chem (2006) 49: 7479-7486 [PMID:17149876]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7	F	5	pIC50	10000	nM	IC50	J Med Chem (2006) 49: 7479-7486 [PMID:17149876]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Inhibition of SARS-CoV-2 papain-like protease	B	4.14	pIC50	72000	nM	IC50	J Med Chem (2022) 65: 7561-7580 [PMID:35620927]
ChEMBL	Inhibition of TAP-tagged SARS-CoV-2 papain-like protease nsp23	B	6	pIC50	1000	nM	IC50	J Med Chem (2022) 65: 7561-7580 [PMID:35620927]
ChEMBL	Inhibition of TAP-tagged SARS-CoV-2 papain-like protease nsp123	B	6.3	pIC50	500	nM	IC50	J Med Chem (2022) 65: 7561-7580 [PMID:35620927]
ChEMBL	Inhibition of SARS-CoV-2 papain-like protease-mediated de-ISGylation	B	7	pIC50	100	nM	IC50	J Med Chem (2022) 65: 7561-7580 [PMID:35620927]
Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713]
ChEMBL	Inhibition of mushroom tyrosinase	B	4.28	pKi	52000	nM	Ki	Eur J Med Chem (2020) 195: 112275-112275 [PMID:32283298]
ubiquitin specific peptidase 2/Ubiquitin carboxyl-terminal hydrolase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293227] [GtoPdb: 2430] [UniProtKB: O75604]
ChEMBL	Inhibition of human USP2 (258 to 605 residues) catalytic domain by fluorescence based assay	B	4.38	pIC50	42000	nM	IC50	Eur J Med Chem (2020) 191: 112107-112107 [PMID:32092586]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL	Inhibition of human xanthine oxidase	B	4.03	pIC50	92420	nM	IC50	Bioorg Med Chem (2007) 15: 3450-3456 [PMID:17379526]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]