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ubiquitin specific peptidase 2

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Target not currently curated in GtoImmuPdb

Target id: 2430

Nomenclature: ubiquitin specific peptidase 2

Family: C19: Ubiquitin-specific protease

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 605 11q23.3 USP2 ubiquitin specific peptidase 2
Mouse - 613 9 A5.1 Usp2 ubiquitin specific peptidase 2
Rat - 618 8q22 Usp2 ubiquitin specific peptidase 2
Previous and Unofficial Names Click here for help
41 kDa ubiquitin-specific protease | deubiquitinating enzyme 2 | ubiquitin carboxyl-terminal hydrolase 2 | ubiquitin specific protease 2 | ubiquitin thioesterase 2 | ubiquitin thiolesterase 2 | ubiquitin-specific-processing protease testis | Ubp41 | UBP-t
Database Links Click here for help
Specialist databases
MEROPS C19.013 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ML364 Small molecule or natural product Hs Inhibition 5.3 pKd 1
pKd 5.3 (Kd 5.2x10-6 M) [1]
Description: Binding affinity for hUSP2
ML364 Small molecule or natural product Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 1.1x10-6 M) [1]
Description: Inhibition of USP2 de-ubiquitinating activity in vitro
MS102 Small molecule or natural product Hs Inhibition - - 1


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1. Dang F, Bai L, Dong J, Hu X, Wang J, Paulo JA, Xiong Y, Liang X, Sun Y, Chen Y et al.. (2023) USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice. Sci Transl Med, 15 (725): eadh7668. [PMID:38055802]

How to cite this page

C19: Ubiquitin-specific protease: ubiquitin specific peptidase 2. Last modified on 12/12/2023. Accessed on 21/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,