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C19: Ubiquitin-specific protease

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The ubiquitin specific peptidases (USPs) are deubiquitinating enzymes (DUBs) that cleave ubiquitin from target proteins. In humans there are ~100 DUBs, that are classified as either cysteine proteases or metalloproteases. There are 58 (human) USPs in the cysteine proteases class.

Enzymes

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ubiquitin specific peptidase 1 Show summary » More detailed page go icon to follow link

ubiquitin specific peptidase 2 Show summary » More detailed page go icon to follow link

ubiquitin specific peptidase 5 Show summary » More detailed page go icon to follow link

ubiquitin specific peptidase 8 Show summary »

ubiquitin specific peptidase 14 Show summary » More detailed page go icon to follow link

ubiquitin specific peptidase 21 Show summary »

References

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How to cite this family page

Database page citation:

C19: Ubiquitin-specific protease. Accessed on 23/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=730.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.