ubiquitin specific peptidase 5 | C19: Ubiquitin-specific protease | IUPHAR/BPS Guide to PHARMACOLOGY

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ubiquitin specific peptidase 5

Target not currently curated in GtoImmuPdb

Target id: 2431

Nomenclature: ubiquitin specific peptidase 5

Family: C19: Ubiquitin-specific protease

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 858 12p13 USP5 ubiquitin specific peptidase 5
Mouse - 858 6 F2 Usp5 ubiquitin specific peptidase 5 (isopeptidase T)
Rat - 858 4q42 Usp5 ubiquitin specific peptidase 5
Previous and Unofficial Names
deubiquitinating enzyme 5 | IsoT | ubiquitin carboxy terminal hydrolase T | ubiquitin carboxyl-terminal hydrolase 5 | ubiquitin specific protease 5 | ubiquitin thioesterase 5 | ubiquitin thiolesterase 5 | Ucht | ubiquitin specific peptidase 5 (isopeptidase T)
Database Links
Specialist databases
MEROPS C19.001 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
vialinin A Hs Inhibition 5.4 pKi 1
pKi 5.4 (Ki 4x10-6 M) [1]
Immuno Process Associations
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0016567 protein ubiquitination TAS


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1. Okada K, Ye YQ, Taniguchi K, Yoshida A, Akiyama T, Yoshioka Y, Onose J, Koshino H, Takahashi S, Yajima A et al.. (2013) Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg. Med. Chem. Lett., 23 (15): 4328-31. [PMID:23791076]

How to cite this page

C19: Ubiquitin-specific protease: ubiquitin specific peptidase 5. Last modified on 28/07/2015. Accessed on 04/06/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2431.