ubiquitin specific peptidase 1 | C19: Ubiquitin-specific protease | IUPHAR/BPS Guide to PHARMACOLOGY

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ubiquitin specific peptidase 1

Target not currently curated in GtoImmuPdb

Target id: 2428

Nomenclature: ubiquitin specific peptidase 1

Family: C19: Ubiquitin-specific protease

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 785 1p31.3 USP1 ubiquitin specific peptidase 1
Mouse - 784 4 C6 Usp1 ubiquitin specific peptidase 1
Rat - 784 5q33 Usp1 ubiquitin specific peptidase 1
Previous and Unofficial Names
deubiquitinating enzyme 1 | ubiquitin carboxyl-terminal hydrolase 1 | ubiquitin specific protease 1 | ubiquitin thioesterase 1 | ubiquitin thiolesterase 1
Database Links
Specialist databases
MEROPS C19.019 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.19.12

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ML323 Hs Inhibition 7.1 pIC50 1
pIC50 7.1 (IC50 7.6x10-8 M) [1]

References

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1. Dexheimer TS, Rosenthal AS, Luci DK, Liang Q, Villamil MA, Chen J, Sun H, Kerns EH, Simeonov A, Jadhav A et al.. (2014) Synthesis and Structure-Activity Relationship Studies of N-Benzyl-2-phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity against Nonsmall Cell Lung Cancer. J. Med. Chem., 57 (19): 8099-110. [PMID:25229643]

How to cite this page

C19: Ubiquitin-specific protease: ubiquitin specific peptidase 1. Last modified on 05/11/2014. Accessed on 22/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2428.