ubiquitin specific peptidase 1 | C19: Ubiquitin-specific protease | IUPHAR/BPS Guide to PHARMACOLOGY

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ubiquitin specific peptidase 1

Target not currently curated in GtoImmuPdb

Target id: 2428

Nomenclature: ubiquitin specific peptidase 1

Family: C19: Ubiquitin-specific protease

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 785 1p31.3 USP1 ubiquitin specific peptidase 1
Mouse - 784 4 C6 Usp1 ubiquitin specific peptidase 1
Rat - 784 5q33 Usp1 ubiquitin specific peptidase 1
Previous and Unofficial Names
deubiquitinating enzyme 1 | ubiquitin carboxyl-terminal hydrolase 1 | ubiquitin specific protease 1 | ubiquitin thioesterase 1 | ubiquitin thiolesterase 1
Database Links
Specialist databases
MEROPS C19.019 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ML323 Hs Inhibition 7.1 pIC50 1
pIC50 7.1 (IC50 7.6x10-8 M) [1]


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1. Dexheimer TS, Rosenthal AS, Luci DK, Liang Q, Villamil MA, Chen J, Sun H, Kerns EH, Simeonov A, Jadhav A et al.. (2014) Synthesis and Structure-Activity Relationship Studies of N-Benzyl-2-phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity against Nonsmall Cell Lung Cancer. J. Med. Chem., 57 (19): 8099-110. [PMID:25229643]

How to cite this page

C19: Ubiquitin-specific protease: ubiquitin specific peptidase 1. Last modified on 05/11/2014. Accessed on 07/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2428.