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ubiquitin specific peptidase 14

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Target not currently curated in GtoImmuPdb

Target id: 2429

Nomenclature: ubiquitin specific peptidase 14

Family: C19: Ubiquitin-specific protease

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 494 18p11.32 USP14 ubiquitin specific peptidase 14
Mouse - 493 18 4.91 cM Usp14 ubiquitin specific peptidase 14
Rat - 493 18p13 Usp14 ubiquitin specific peptidase 14
Previous and Unofficial Names Click here for help
deubiquitinating enzyme 14 | TGT | ubiquitin carboxyl-terminal hydrolase 14 | ubiquitin specific protease 14 | ubiquitin thioesterase 14 | ubiquitin thiolesterase 14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Database Links Click here for help
Specialist databases
MEROPS C19.015 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
VLX1570 Small molecule or natural product Primary target of this compound Hs Inhibition 4.7 – 5.8 pKd 2
pKd 4.7 – 5.8 (Kd 1.8x10-5 – 1.5x10-6 M) [2]
Description: Surface plasmon resonance assay using recombinant human USP14.
IU1 Small molecule or natural product Ligand has a PDB structure Hs Inhibition 5.3 pIC50 1
pIC50 5.3 (IC50 4.7x10-6 M) [1]
Description: Measuring inhibition of Ub–AMC hydrolysis by proteasome-bound USP14
Immuno Process Associations
Immuno Process:  Inflammation


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1. Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP et al.. (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature, 467 (7312): 179-84. [PMID:20829789]

2. Wang X, Mazurkiewicz M, Hillert EK, Olofsson MH, Pierrou S, Hillertz P, Gullbo J, Selvaraju K, Paulus A, Akhtar S et al.. (2016) The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep, 6: 26979. [PMID:27264969]

How to cite this page

C19: Ubiquitin-specific protease: ubiquitin specific peptidase 14. Last modified on 02/12/2016. Accessed on 11/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY,