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Target not currently curated in GtoImmuPdb
Target id: 2429
Nomenclature: ubiquitin specific peptidase 14
Family: C19: Ubiquitin-specific protease
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 494 | 18p11.32 | USP14 | ubiquitin specific peptidase 14 | |
Mouse | - | 493 | 18 4.91 cM | Usp14 | ubiquitin specific peptidase 14 | |
Rat | - | 493 | 18p13 | Usp14 | ubiquitin specific peptidase 14 |
Database Links | |
Specialist databases | |
MEROPS | C19.015 (Hs) |
Other databases | |
Alphafold | P54578 (Hs), Q9JMA1 (Mm) |
BRENDA | 3.4.19.12 |
ChEMBL Target | CHEMBL1293295 (Hs) |
Ensembl Gene | ENSG00000101557 (Hs), ENSMUSG00000047879 (Mm), ENSRNOG00000014981 (Rn) |
Entrez Gene | 9097 (Hs), 59025 (Mm), 291796 (Rn) |
Human Protein Atlas | ENSG00000101557 (Hs) |
KEGG Enzyme | 3.4.19.12 |
KEGG Gene | hsa:9097 (Hs), mmu:59025 (Mm), rno:291796 (Rn) |
OMIM | 607274 (Hs) |
Pharos | P54578 (Hs) |
RefSeq Nucleotide | NM_005151 (Hs), NM_001037334 (Hs), NM_021522 (Mm), NM_001008301 (Rn) |
RefSeq Protein | NP_001032411 (Hs), NP_005142 (Hs), NP_067497 (Mm), NP_001008302 (Rn) |
UniProtKB | P54578 (Hs), Q9JMA1 (Mm) |
Wikipedia | USP14 (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Immuno Process Associations | ||
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1. Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP et al.. (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature, 467 (7312): 179-84. [PMID:20829789]
2. Wang X, Mazurkiewicz M, Hillert EK, Olofsson MH, Pierrou S, Hillertz P, Gullbo J, Selvaraju K, Paulus A, Akhtar S et al.. (2016) The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep, 6: 26979. [PMID:27264969]
C19: Ubiquitin-specific protease: ubiquitin specific peptidase 14. Last modified on 02/12/2016. Accessed on 15/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2429.