Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	494	18p11.32	USP14	ubiquitin specific peptidase 14
Mouse	-	493	18 4.91 cM	Usp14	ubiquitin specific peptidase 14
Rat	-	493	18p13	Usp14	ubiquitin specific peptidase 14

Previous and Unofficial Names

deubiquitinating enzyme 14 | TGT | ubiquitin carboxyl-terminal hydrolase 14 | ubiquitin specific protease 14 | ubiquitin thioesterase 14 | ubiquitin thiolesterase 14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

Database Links
Specialist databases
MEROPS	C19.015 (Hs)
Other databases
Alphafold	P54578 (Hs), Q9JMA1 (Mm)
BRENDA	3.4.19.12
ChEMBL Target	CHEMBL1293295 (Hs)
Ensembl Gene	ENSG00000101557 (Hs), ENSMUSG00000047879 (Mm), ENSRNOG00000014981 (Rn)
Entrez Gene	9097 (Hs), 59025 (Mm), 291796 (Rn)
Human Protein Atlas	ENSG00000101557 (Hs)
KEGG Enzyme	3.4.19.12
KEGG Gene	hsa:9097 (Hs), mmu:59025 (Mm), rno:291796 (Rn)
OMIM	607274 (Hs)
Pharos	P54578 (Hs)
RefSeq Nucleotide	NM_005151 (Hs), NM_001037334 (Hs), NM_021522 (Mm), NM_001008301 (Rn)
RefSeq Protein	NP_001032411 (Hs), NP_005142 (Hs), NP_067497 (Mm), NP_001008302 (Rn)
UniProtKB	P54578 (Hs), Q9JMA1 (Mm)
Wikipedia	USP14 (Hs)

Enzyme Reaction
EC Number: 3.4.19.12

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference VLX1570 Hs Inhibition 4.7 – 5.8 pKd 2 ⤷ pKd 4.7 – 5.8 (Kd 1.8x10-5 – 1.5x10-6 M) [2] Description: Surface plasmon resonance assay using recombinant human USP14. IU1 Hs Inhibition 5.3 pIC50 1 ⤷ pIC50 5.3 (IC50 4.7x10-6 M) [1] Description: Measuring inhibition of Ub–AMC hydrolysis by proteasome-bound USP14

Immuno Process Associations

Immuno Process:  Inflammation