ubiquitin specific peptidase 14 | C19: Ubiquitin-specific protease | IUPHAR/BPS Guide to PHARMACOLOGY

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ubiquitin specific peptidase 14

Target not currently curated in GtoImmuPdb

Target id: 2429

Nomenclature: ubiquitin specific peptidase 14

Family: C19: Ubiquitin-specific protease

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 494 18p11.32 USP14 ubiquitin specific peptidase 14
Mouse - 493 18 A1 Usp14 ubiquitin specific peptidase 14
Rat - 493 18p13 Usp14 ubiquitin specific peptidase 14
Previous and Unofficial Names
deubiquitinating enzyme 14 | TGT | ubiquitin carboxyl-terminal hydrolase 14 | ubiquitin specific protease 14 | ubiquitin thioesterase 14 | ubiquitin thiolesterase 14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Database Links
Specialist databases
MEROPS C19.015 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
VLX1570 Hs Inhibition 4.7 – 5.8 pKd 2
pKd 4.7 – 5.8 (Kd 1.8x10-5 – 1.5x10-6 M) [2]
Description: Surface plasmon resonance assay using recombinant human USP14.
IU1 Hs Inhibition 5.3 pIC50 1
pIC50 5.3 (IC50 4.7x10-6 M) [1]
Description: Measuring inhibition of Ub–AMC hydrolysis by proteasome-bound USP14
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045087 innate immune response IEA


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1. Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP et al.. (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature, 467 (7312): 179-84. [PMID:20829789]

2. Wang X, Mazurkiewicz M, Hillert EK, Olofsson MH, Pierrou S, Hillertz P, Gullbo J, Selvaraju K, Paulus A, Akhtar S et al.. (2016) The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep, 6: 26979. [PMID:27264969]

How to cite this page

C19: Ubiquitin-specific protease: ubiquitin specific peptidase 14. Last modified on 02/12/2016. Accessed on 12/07/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2429.