phenylthiocarbamide [Ligand Id: 12496] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL263376 (1-Phenylthiourea, N-Phenylthiourea, N-Phenyl-Thiourea, Phenylthiourea) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Succinyl-diaminopimelate desuccinylase in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075192] [UniProtKB: P44514] | ||||||||
| ChEMBL | Inhibition of Haemophilus influenzae recombinant DapE | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6350-6352 [PMID:19822427] |
| TAS2R38/Taste receptor type 2 member 38 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523248] [GtoPdb: 682] [UniProtKB: P59533] | ||||||||
| GtoPdb | - | - | 5.68 | pEC50 | 2100 | nM | EC50 | Curr Biol (2005) 15: 322-7 [PMID:15723792] |
| ChEMBL | Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay | F | 5.7 | pEC50 | 2000 | nM | EC50 | EP-2267129-B1. Bitter taste receptors (null) |
| Tyrosinase in Agaricus bisporus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3318] [UniProtKB: O42713] | ||||||||
| ChEMBL | Competitive inhibition of mushroom tyrosinase using L-tyrosine as substrate by Lineweaver-Burk plots analysis | B | 6.52 | pKi | 300 | nM | Ki | Eur J Med Chem (2015) 106: 157-166 [PMID:26544630] |
| ChEMBL | Inhibition of mushroom tyrosinase | B | 5.74 | pIC50 | 1800 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3607-3610 [PMID:18501598] |
| ChEMBL | Inhibition of mushroom tyrosinase activity using L-tyrosine as substrate by spectrometric analysis | B | 5.82 | pIC50 | 1500 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 6824-6828 [PMID:21978680] |
| ChEMBL | Inhibition of mushroom tyrosinase using L-tyrosine as substrate | B | 5.89 | pIC50 | 1300 | nM | IC50 | Eur J Med Chem (2015) 106: 157-166 [PMID:26544630] |
| tyrosinase/Tyrosinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1973] [GtoPdb: 2643] [UniProtKB: P14679] | ||||||||
| ChEMBL | Uncompetitive inhibition of recombinant human tyrosinase expressed in baculovirus infected sf9 cells using L-DOPA as substrate by double-reciprocal plot analysis | B | 5.77 | pKi | 1700 | nM | Ki | J Med Chem (2020) 63: 13428-13443 [PMID:32787103] |
| ChEMBL | Inhibition of tyrosinase | B | 5.74 | pIC50 | 1800 | nM | IC50 | Bioorg Med Chem (2010) 18: 1555-1562 [PMID:20097083] |
| tyrosinase/Tyrosinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5346] [GtoPdb: 2643] [UniProtKB: P11344] | ||||||||
| ChEMBL | Inhibition of tyrosinase in alpha-MSH-induced mouse B16 cells | B | 5.74 | pIC50 | 1800 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4771-4773 [PMID:20638280] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
