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ChEMBL ligand: CHEMBL4162752 (Ddo-3055) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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egl-9 family hypoxia inducible factor 1/Egl nine homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5697] [GtoPdb: 2833] [UniProtKB: Q9GZT9] | ||||||||
ChEMBL | Inhibition of HIF-PHD2 (unknown origin) by fluorescence polarization assay | B | 4.86 | pIC50 | 13700 | nM | IC50 | J Med Chem (2018) 61: 6964-6982 [PMID:29712435] |
GtoPdb | - | - | 7.19 | pIC50 | 64.2 | nM | IC50 | J Med Chem (2020) 63: 10045-10060 [PMID:32787144] |
ChEMBL | Inhibition of FITC-HIF1alpha (556 to 574 residues) binding to PHD2 (181 to 426 residues) (unknown origin) by fluorescence polarization assay | B | 7.19 | pIC50 | 64.2 | nM | IC50 | J Med Chem (2020) 63: 10045-10060 [PMID:32787144] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]