Synonyms: compound 16e [PMID: 30525599] | Jeselhy® | TAS-116 | TAS116
Compound class:
Synthetic organic
Comment: Pimitespib (TAS-116) is an orally bioavailable heat shock protein 90 α/β (HSP90α/β) inhibitor [6], that promotes proteasomal degradation of oncogenic HSP90 client proteins, and induces apoptosis of cells that overexpress (HSP90α/β). Reported to bind at the N-terminal ATP binding site of the target proteins [6]. Pimitespib was developed for potential antineoplastic activity [1,3-5].
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
3-ethyl-4-[4-[4-(1-methylpyrazol-4-yl)imidazol-1-yl]-3-propan-2-ylpyrazolo[3,4-b]pyridin-1-yl]benzamide |
International Nonproprietary Names | |
INN number | INN |
11079 | pimitespib |
Synonyms |
compound 16e [PMID: 30525599] | Jeselhy® | TAS-116 | TAS116 |
Database Links | |
BindingDB Ligand | 126083 |
CAS Registry No. | 1260533-36-5 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL3661115 |
DrugBank Ligand | DB14876 |
GtoPdb PubChem SID | 473153872 |
PubChem CID | 67501411 |
Search Google for chemical match using the InChIKey | NVVPMZUGELHVMH-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | NVVPMZUGELHVMH |
Search PubMed clinical trials | pimitespib |
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UniChem Compound Search for chemical match using the InChIKey | NVVPMZUGELHVMH-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NVVPMZUGELHVMH-UHFFFAOYSA-N |