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ChEMBL ligand: CHEMBL142009 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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OX1 receptor/Orexin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5113] [GtoPdb: 321] [UniProtKB: O43613] | ||||||||
ChEMBL | Inhibitory concentration against human orexin-1 receptor (hOX1R) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2003) 13: 4497-4499 [PMID:14643355] |
ChEMBL | Antagonist activity at human OX1 receptor | F | 5 | pIC50 | >10000 | nM | IC50 | J. Med. Chem. (2009) 52: 891-903 [PMID:19199652] |
ChEMBL | Binding affinity to orexin receptor 1 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2013) 23: 4761-4769 [PMID:23891187] |
OX2 receptor/Orexin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4792] [GtoPdb: 322] [UniProtKB: O43614] | ||||||||
GtoPdb | - | - | 7.5 | pKi | - | - | - |
Bioorg Med Chem Lett (2003) 13: 4497-9 [PMID:14643355]; Br J Pharmacol (2014) 171: 351-63 [PMID:23692283] |
ChEMBL | Inhibitory concentration against human orexin-2 receptor (hOX2R) | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg. Med. Chem. Lett. (2003) 13: 4497-4499 [PMID:14643355] |
ChEMBL | Antagonist activity at human OX2 receptor | F | 7.4 | pIC50 | 40 | nM | IC50 | J. Med. Chem. (2009) 52: 891-903 [PMID:19199652] |
ChEMBL | Binding affinity to orexin receptor 2 (unknown origin) | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg. Med. Chem. Lett. (2013) 23: 4761-4769 [PMID:23891187] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]