TCS-OX2-29 [Ligand Id: 4038] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL142009 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OX1 receptor/Orexin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5113] [GtoPdb: 321] [UniProtKB: O43613] | ||||||||
| ChEMBL | Inhibitory concentration against human orexin-1 receptor (hOX1R) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 4497-4499 [PMID:14643355] |
| ChEMBL | Antagonist activity at human OX1 receptor | F | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2009) 52: 891-903 [PMID:19199652] |
| ChEMBL | Binding affinity to orexin receptor 1 (unknown origin) | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4761-4769 [PMID:23891187] |
| OX2 receptor/Orexin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4792] [GtoPdb: 322] [UniProtKB: O43614] | ||||||||
| GtoPdb | - | - | 7.5 | pKi | - | - | - |
Bioorg Med Chem Lett (2003) 13: 4497-9 [PMID:14643355]; Br J Pharmacol (2014) 171: 351-63 [PMID:23692283] |
| ChEMBL | Inhibitory concentration against human orexin-2 receptor (hOX2R) | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 4497-4499 [PMID:14643355] |
| ChEMBL | Antagonist activity at human OX2 receptor | F | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2009) 52: 891-903 [PMID:19199652] |
| ChEMBL | Binding affinity to orexin receptor 2 (unknown origin) | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4761-4769 [PMID:23891187] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
