monomethyl fumarate [Ligand Id: 5786] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL589586 (Bafiertam, Fumaric acid monomethyl ester, Methyl Fumarate, Monomethyl fumarate, NSC-523835)
  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
GtoPdb - - 6.74 pKi 180 nM Ki Bioorg Med Chem Lett (2011) 21: 2736-9 [PMID:21167710]
ChEMBL Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting B 6.74 pKi 180 nM Ki Bioorg Med Chem Lett (2011) 21: 2736-2739 [PMID:21167710]
GtoPdb - - 5.03 pEC50 9400 nM EC50 Biochem Biophys Res Commun (2008) 375: 562-5 [PMID:18722346]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]