monomethyl fumarate [Ligand Id: 5786] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL589586 (Monomethyl fumarate, Methyl Fumarate, Bafiertam)
  • HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
HCA2 receptor/Hydroxycarboxylic acid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3785] [GtoPdb: 312] [UniProtKB: Q8TDS4]
GtoPdb - - 6.74 pKi 180 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 2736-9 [PMID:21167710]
ChEMBL Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation counting B 6.74 pKi 180 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 2736-2739 [PMID:21167710]
GtoPdb - - 5.03 pEC50 9400 nM EC50 Biochem. Biophys. Res. Commun. (2008) 375: 562-5 [PMID:18722346]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]