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ChEMBL ligand: CHEMBL90555 (22-oxovincaleukoblastine, Leucristine, Leurocristine, Oncotcs, Tecnocris, Vincaleukoblastine, 22-oxo-, Vincristin, Vincristine, Vinkristin) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Beta tubulin in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3186] [UniProtKB: Q25270] | ||||||||
ChEMBL | Compound was tested for inhibition of tubulin polymerisation | F | 6 | pIC50 | <1000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2004) 14: 6075-6078 [PMID:15546733] |
ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.05 uM) in membrane vesicle from MRP1-expressing HeLa cells | F | 4.15 | pIC50 | 70000 | nM | IC50 | J. Biol. Chem. (1996) 271: 9683-9689 [PMID:8621644] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay | F | 9 | pIC50 | 1 | nM | IC50 | Antimicrob. Agents Chemother. (2010) 54: 3597-3604 [PMID:20547797] |
tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7] | ||||||||
ChEMBL | The compound tested for the inhibition of tubulin polymerization. | F | 6.3 | pIC50 | 500 | nM | IC50 | J. Med. Chem. (1991) 34: 1998-2003 [PMID:2066973] |
Tubulin alpha chain in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3658] [UniProtKB: P02550] | ||||||||
ChEMBL | The compound was evaluated in vitro for the mammalian brain tubulin polymerization using standard assay. | F | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg. Med. Chem. Lett. (1992) 2: 1257-1262 |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]