vincristine [Ligand Id: 6785] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL90555 (22-oxovincaleukoblastine, Leucristine, Leurocristine, Oncotcs, Tecnocris, Vincaleukoblastine, 22-oxo-, Vincristin, Vincristine, Vinkristin)
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  • ABCC1/Multidrug resistance-associated protein 1 in Human [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta tubulin in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3186] [UniProtKB: Q25270]
ChEMBL Compound was tested for inhibition of tubulin polymerisation F 6 pIC50 <1000 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 6075-6078 [PMID:15546733]
ABCC1/Multidrug resistance-associated protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3004] [GtoPdb: 779] [UniProtKB: P33527]
ChEMBL TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.05 uM) in membrane vesicle from MRP1-expressing HeLa cells F 4.15 pIC50 70000 nM IC50 J. Biol. Chem. (1996) 271: 9683-9689 [PMID:8621644]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay F 9 pIC50 1 nM IC50 Antimicrob. Agents Chemother. (2010) 54: 3597-3604 [PMID:20547797]
tubulin beta class I/tubulin alpha 4a/tubulin beta 4B class IVb/tubulin beta 3 class III/tubulin beta 8 class VIII/tubulin alpha 1a/Tubulin in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095182] [GtoPdb: 2640, 2639, 2641, 2752, 2753, 2638] [UniProtKB: P04350, P07437, P0DPH7, P68363, P68366, P68371, Q13509, Q13885, Q3ZCM7, Q6PEY2, Q71U36, Q9BQE3, Q9BUF5, Q9BVA1, Q9H4B7]
ChEMBL The compound tested for the inhibition of tubulin polymerization. F 6.3 pIC50 500 nM IC50 J. Med. Chem. (1991) 34: 1998-2003 [PMID:2066973]
Tubulin alpha chain in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3658] [UniProtKB: P02550]
ChEMBL The compound was evaluated in vitro for the mammalian brain tubulin polymerization using standard assay. F 6.66 pIC50 220 nM IC50 Bioorg. Med. Chem. Lett. (1992) 2: 1257-1262

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]