vincristine

Ligand id: 6785

Name: vincristine

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 12
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 171.17
Molecular weight 824.4
XLogP 3.56
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Natural product or derivative
Approved drug? Yes (FDA (1963))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
International Nonproprietary Names
INN number INN
1440 vincristine
Synonyms
22-oxovincaleukoblastine | kyocristine | leurocristine sulfate | NSC-67574 | Oncovin®
Comments
A pan tubulin inhibitor, isolated from Catharanthus roseus (the Madagascar periwinkle, formerly Vinca rosea). Marketed formulations contain vincristine sulfate (PubChem CID 249332).
Database Links
CAS Registry No. 57-22-7
ChEBI CHEBI:28445
ChEMBL Ligand CHEMBL90555
DrugBank Ligand DB00541
GtoPdb PubChem SID 178103391
Immunopaedia Search vincristine
PubChem CID 5978
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Wikipedia Vincristine