vincristine   Click here for help

GtoPdb Ligand ID: 6785

Synonyms: 22-oxovincaleukoblastine | kyocristine | leurocristine sulfate | NSC-67574 | Oncovin®
Approved drug
vincristine is an approved drug (FDA (1963))
Comment: A pan tubulin inhibitor, isolated from Catharanthus roseus (the Madagascar periwinkle, formerly Vinca rosea). Marketed formulations contain vincristine sulfate (PubChem CID 249332).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 12
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 171.17
Molecular weight 824.4
XLogP 3.56
No. Lipinski's rules broken 1
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Canonical SMILES O=CN1c2cc(OC)c(cc2C23C1C(O)(C(=O)OC)C(OC(=O)C)C1(C3N(CC2)CC=C1)CC)C1(CC2CN(CCc3c1[nH]c1c3cccc1)CC(C2)(O)CC)C(=O)OC
Isomeric SMILES O=CN1c2cc(OC)c(cc2[C@]23[C@@H]1[C@@](O)(C(=O)OC)[C@H](OC(=O)C)[C@]1([C@@H]3N(CC2)CC=C1)CC)[C@]1(C[C@@H]2CN(CCc3c1[nH]c1c3cccc1)C[C@](C2)(O)CC)C(=O)OC
InChI InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1
Classification Click here for help
Compound class Natural product or derivative
Approved drug? Yes (FDA (1963))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
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International Nonproprietary Names Click here for help
INN number INN
1440 vincristine
Synonyms Click here for help
22-oxovincaleukoblastine | kyocristine | leurocristine sulfate | NSC-67574 | Oncovin®
Database Links Click here for help
CAS Registry No. 57-22-7
ChEMBL Ligand CHEMBL90555
DrugBank Ligand DB00541
GtoPdb PubChem SID 178103391
Immunopaedia Search vincristine
PubChem CID 5978
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UniChem Compound Search for chemical match using the InChIKey OGWKCGZFUXNPDA-XQKSVPLYSA-N
UniChem Connectivity Search for chemical match using the InChIKey OGWKCGZFUXNPDA-XQKSVPLYSA-N
Wikipedia Vincristine