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tubulin beta 3 class III

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Target not currently curated in GtoImmuPdb

Target id: 2752

Nomenclature: tubulin beta 3 class III

Family: Tubulins

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 450 16q24.3 TUBB3 tubulin beta 3 class III
Mouse - 450 8 E1 Tubb3 tubulin, beta 3 class III
Rat - 450 19q12 Tubb3 tubulin, beta 3 class III
Previous and Unofficial Names Click here for help
FEOM3 | tubulin, beta 3 class III | tubulin
Database Links Click here for help
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
combretastatin A4 Small molecule or natural product Ligand has a PDB structure Hs Inhibition 8.2 pIC50 1
pIC50 8.2 (IC50 5.7x10-9 M) [1]
Description: Measuring cytotoxicity in cells expressing TUBB3 using the sulforhodamine B colorimetric assay.
Inhibitor Comments
Please see the Inhibitors table on the More detailed page for TUBB, for information on approved drugs which may act via this protein.
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Cortical dysplasia, complex, with other brain malformations 1; CDCBM1
Synonyms: Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation
OMIM: 614039
Orphanet: ORPHA300570
Disease:  Fibrosis of extraocular muscles, congenital, 3A, with or without extraocular involvement; CFEOM3A
Synonyms: Congenital fibrosis of extraocular muscles [Orphanet: ORPHA45358]
OMIM: 600638
Orphanet: ORPHA45358

References

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1. Gangjee A, Zhao Y, Raghavan S, Rohena CC, Mooberry SL, Hamel E. (2013) Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents. J. Med. Chem., 56 (17): 6829-44. [PMID:23895532]

How to cite this page

Tubulins: tubulin beta 3 class III. Last modified on 29/01/2016. Accessed on 02/12/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2752.