APA [Ligand Id: 5139] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL281021
  • Mitochondrial oxodicarboxylate carrier/Mitochondrial 2-oxodicarboxylate carrier in Mouse [ChEMBL: CHEMBL6196107] [GtoPdb: 1057] [UniProtKB: Q8BZ09]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Mitochondrial oxodicarboxylate carrier/Mitochondrial 2-oxodicarboxylate carrier in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6196107] [GtoPdb: 1057] [UniProtKB: Q8BZ09]
ChEMBL Competitive inhibition of mouse kidney ODC assessed as inhibition constant B 5.49 pKi 3200 nM Ki J Med Chem (2025) 68: 5760-5773 [PMID:40035393]
Ornithine decarboxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1869] [GtoPdb: 1276] [UniProtKB: P11926]
ChEMBL Inhibition of full length C-terminal his-6 tagged human ODC extracted from Escherichia coli BL21 (DE3) cells incubated for 30 mins by liquid scintillation analysis B 7.4 pIC50 40 nM IC50 J Med Chem (2025) 68: 5760-5773 [PMID:40035393]
GtoPdb - - 7.46 pIC50 35 nM IC50 J Med Chem (1992) 35: 1339-44 [PMID:1573631]
Ornithine decarboxylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3511] [GtoPdb: 1276] [UniProtKB: P09057]
ChEMBL Inhibitory activity against Rat liver ornithine decarboxylase (ODC) B 7.46 pIC50 35 nM IC50 J Med Chem (1992) 35: 1339-1344 [PMID:1573631]
Spermine synthase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6196095] [UniProtKB: Q3SZA5]
ChEMBL Irreversible inhibition of spermidine synthase in bovine brain assessed as inhibition constant B 5.64 pKi 2300 nM Ki J Med Chem (2025) 68: 5760-5773 [PMID:40035393]

ChEMBL data shown on this page come from version 37:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]