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ChEMBL ligand: CHEMBL2158866 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
ChEMBL | Inhibition of CDK1 | B | 4.49 | pIC50 | 32000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2 | B | 5.15 | pIC50 | 7100 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994] |
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
ChEMBL | Inhibition of GSK3alpha | B | 6.59 | pIC50 | 260 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3beta | B | 6.48 | pIC50 | 330 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
ChEMBL | Inhibition of PI3Kalpha using diC8-tagged PIP2 as substrate after 30 to 60 mins by TAMRA-based fluorescence polarization assay | B | 7.04 | pIC50 | 92 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994] |
GtoPdb | - | - | 7.04 | pIC50 | 92 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-41 [PMID:23021994] |
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
GtoPdb | - | - | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-41 [PMID:23021994] |
ChEMBL | Inhibition of PI3Kgamma using diC8-tagged PIP2 as substrate after 30 to 60 mins by TAMRA-based fluorescence polarization assay | B | 7.22 | pIC50 | 60 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994] |
mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] | ||||||||
GtoPdb | - | - | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-41 [PMID:23021994] |
ChEMBL | Inhibition of mTOR | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994] |
SMG1 nonsense mediated mRNA decay associated PI3K related kinase/Serine/threonine-protein kinase SMG1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795195] [GtoPdb: 2201] [UniProtKB: Q96Q15] | ||||||||
ChEMBL | Inhibition of human recombinant SMG1 expressed in HEK293 cells using GST-tagged p53 as substrate after 1 hr by DELFIA assay | B | 9.96 | pIC50 | 0.11 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-6641 [PMID:23021994] |
GtoPdb | - | - | 9.96 | pIC50 | 0.11 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6636-41 [PMID:23021994] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]