SMG1 nonsense mediated mRNA decay associated PI3K related kinase | SMG1 subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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SMG1 nonsense mediated mRNA decay associated PI3K related kinase

Target not currently curated in GtoImmuPdb

Target id: 2201

Nomenclature: SMG1 nonsense mediated mRNA decay associated PI3K related kinase

Abbreviated Name: SMG1

Family: SMG1 subfamily

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 3661 16p12.3 SMG1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Mouse - 3658 7 F2 Smg1 SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)
Rat - 3567 1q35 Smg1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase
Previous and Unofficial Names
ATX | LIP | SMG1 phosphatidylinositol 3-kinase-related kinase | SMG1, nonsense mediated mRNA decay associated PI3K related kinase | SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) | SMG1 | SMG1 homolog
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 11j [PMID: 23021994] Hs Inhibition 10.0 pIC50 3
pIC50 10.0 (IC50 1.1x10-10 M) [3]
General Comments
Given SMG1's role in ensuring integrity of translated proteins [1-2,4-5], and the observation that some disease phenotypes result from aberrant translation of truncated, partially functional proteins, SMG1 has become as a interventional molecular target. Therapeutic inhibitors of SMG1 are being sought [3].

References

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1. Abraham RT. (2004) The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. DNA Repair (Amst.), 3 (8-9): 919-25. [PMID:15279777]

2. Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP. (2001) Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. J. Biol. Chem., 276 (25): 22709-14. [PMID:11331269]

3. Gopalsamy A, Bennett EM, Shi M, Zhang WG, Bard J, Yu K. (2012) Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg. Med. Chem. Lett., 22 (21): 6636-41. [PMID:23021994]

4. Pulak R, Anderson P. (1993) mRNA surveillance by the Caenorhabditis elegans smg genes. Genes Dev., 7 (10): 1885-97. [PMID:8104846]

5. Yamashita A, Kashima I, Ohno S. (2005) The role of SMG-1 in nonsense-mediated mRNA decay. Biochim. Biophys. Acta, 1754 (1-2): 305-15. [PMID:16289965]

How to cite this page

SMG1 subfamily: SMG1 nonsense mediated mRNA decay associated PI3K related kinase. Last modified on 27/03/2019. Accessed on 23/01/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2201.