ChEMBL ligand: CHEMBL588619 ((8r,9s)-cinchonine, (9s)-cinchonan-9-ol, Cinchonan-9-ol, (9s)-, D-cinchonine, GNF-Pf-3189, NSC-6176, TCMDC-123933)
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	4.64	pIC50	23000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase assay	F	6.53	pIC50	292.5	nM	IC50	Eur J Med Chem (2015) 100: 10-17 [PMID:26063305]
ChEMBL	In vitro antimalarial activity against Plasmodium falciparum W2 in human erythrocytes by [3H]hypoxanthine uptake	F	6.66	pIC50	220	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL	Antimalarial activity against chloroquine resistant Plasmodium falciparum Dd2 after 72 hrs by SYBP Green I dye staining	F	7.09	pIC50	82	nM	IC50	Bioorg Med Chem (2012) 20: 3292-3297 [PMID:22512909]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method	F	7.25	pIC50	56	nM	IC50	Med Chem Res (2007) 16: 213-229
ChEMBL	In vitro inhibition of parasite development of Plasmodium falciparum W2 in human erythrocytes	F	7.29	pIC50	51	nM	IC50	Bioorg Med Chem Lett (2002) 12: 1351-1355 [PMID:11992775]
ChEMBL	Antimalarial activity against chloroquine sensitive Plasmodium falciparum HB3 after 72 hrs by SYBP Green I dye staining	F	7.66	pIC50	22	nM	IC50	Bioorg Med Chem (2012) 20: 3292-3297 [PMID:22512909]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as incorporation of [3H]hypoxanthine after 48 hr microdilution method	F	7.68	pIC50	21	nM	IC50	Med Chem Res (2007) 16: 213-229
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay	F	8.3	pIC50	5	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3597-3604 [PMID:20547797]
ChEMBL	NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay	F	6.96	pEC50	110	nM	EC50	Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783]
ChEMBL	NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay	F	7.02	pEC50	95.3	nM	EC50	Proc Natl Acad Sci U S A (2008) 105: 9059-9064 [PMID:18579783]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]