SMP-797 [Ligand Id: 6729] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL573970 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| acetyl-CoA acetyltransferase 1/Acetyl-CoA acetyltransferase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2616] [GtoPdb: 2435] [UniProtKB: P24752] | ||||||||
| ChEMBL | Inhibition of ACAT1 (unknown origin) | B | 7.51 | pIC50 | 31 | nM | IC50 | Eur J Med Chem (2024) 270: 116333-116333 [PMID:38569434] |
| acetyl-CoA acetyltransferase 1 in Rat [GtoPdb: 2435] [UniProtKB: P17764] | ||||||||
| GtoPdb | - | - | 7.68 | pIC50 | 21 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 44-8 [PMID:16242323] |
| Sterol O-acyltransferase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL285] [UniProtKB: O70536] | ||||||||
| ChEMBL | Inhibition of ACAT in rat macrophages assessed as incorporation of extracellular [3H]-oleic acid-BSA complex into the intracellular cholesteryl ester after 24 hrs | B | 7.51 | pIC50 | 31 | nM | IC50 | Bioorg Med Chem (2009) 17: 4636-4646 [PMID:19464189] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
