ChEMBL ligand: CHEMBL110739 (11-b,21-Dihydroxypregn-3,20-dione, 17-Deoxycortisol, Corticosteron, Corticosterone, Kendall's compound b, NSC-9705, Preg-4-ene-3,20-dione,11-b,21-dihydroxy-, Reichstein's substance h)
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human [ChEMBL: CHEMBL4931] [UniProtKB: Q15125] There should be some charts here, you may need to enable JavaScript!
Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] There should be some charts here, you may need to enable JavaScript!
C-8 sterol isomerase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL3224] [UniProtKB: P32352] There should be some charts here, you may need to enable JavaScript!
Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
Mineralocorticoid receptor in Human [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] Organic cation transporter 1/Solute carrier family 22 member 1 in Rat [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244] Organic cation transporter 2/Solute carrier family 22 member 2 in Rat [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 3/Solute carrier family 22 member 3 in Human [ChEMBL: CHEMBL2073673] [GtoPdb: 1021] [UniProtKB: O75751] Organic cation transporter 3/Solute carrier family 22 member 3 in Rat [ChEMBL: CHEMBL1770033] [GtoPdb: 1021] [UniProtKB: O88446] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] There should be some charts here, you may need to enable JavaScript!
Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] There should be some charts here, you may need to enable JavaScript!
Glucocorticoid receptor in Mouse [GtoPdb: 625] [UniProtKB: P06537] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4931] [UniProtKB: Q15125]
ChEMBL	Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand	B	4	pKi	>100000	nM	Ki	J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL	Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)	B	4.63	pIC50	23442.29	nM	IC50	J Med Chem (2005) 48: 5666-5674 [PMID:16134935]
C-8 sterol isomerase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3224] [UniProtKB: P32352]
ChEMBL	Affinity for ERG2 of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand	B	4	pKi	>100000	nM	Ki	J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	In silico binding affinity to human corticosteriod binding globulin	B	6.88	pKd	6.88	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	7.2	pKi	63.1	nM	Ki	J Med Chem (2004) 47: 2732-2742 [PMID:15139751]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	7.88	pKi	13.18	nM	Ki	J Med Chem (2004) 47: 2732-2742 [PMID:15139751]
Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235]
ChEMBL	Binding affinity to MR (unknown origin)	B	9.3	pKd	0.5	nM	Kd	J Med Chem (2017) 60: 2629-2650 [PMID:28051871]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	4.9	pIC50	12589.25	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand	B	4.45	pKi	35600	nM	Ki	J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing HeLa cells	F	5.15	pKi	7020	nM	Ki	J Pharmacol Exp Ther (1998) 286: 354-361 [PMID:9655880]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT1-expressing HEK293 cells	F	4.66	pIC50	21700	nM	IC50	Br J Pharmacol (2002) 136: 829-836 [PMID:12110607]
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake in OCT1-expressing HEK293 cells	F	4.14	pKi	72000	nM	Ki	Naunyn Schmiedebergs Arch Pharmacol (1996) 354: 320-326 [PMID:8878062]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake in Xenopus laevis oocytes	F	5	pKi	>10000	nM	Ki	Nature (1994) 372: 549-552 [PMID:7990927]
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT2-expressing HEK293 cells	F	4.47	pIC50	34200	nM	IC50	Br J Pharmacol (2002) 136: 829-836 [PMID:12110607]
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
ChEMBL	TP_TRANSPORTER: inhibition of Serotonin uptake in OCT2-expressing HEK293 cells	F	6.22	pKi	605	nM	Ki	J Biol Chem (1998) 273: 30915-30920 [PMID:9812985]
ChEMBL	TP_TRANSPORTER: inhibition of Noradrenaline uptake in OCT2-expressing HEK293 cells	F	6.34	pKi	460	nM	Ki	J Biol Chem (1998) 273: 30915-30920 [PMID:9812985]
ChEMBL	TP_TRANSPORTER: inhibition of Adrenaline uptake in OCT2-expressing HEK293 cells	F	6.38	pKi	420	nM	Ki	J Biol Chem (1998) 273: 30915-30920 [PMID:9812985]
ChEMBL	TP_TRANSPORTER: inhibition of Dopamine uptake in OCT2-expressing HEK293 cells	F	6.41	pKi	390	nM	Ki	J Biol Chem (1998) 273: 30915-30920 [PMID:9812985]
ChEMBL	TP_TRANSPORTER: inhibition pramipexole uptake in rOCT2-injected oocytes	F	4.97	pIC50	10700	nM	IC50	Drug Metab Dispos (2005) 33: 495-499 [PMID:15640376]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT2-expressing HRPE cells	F	5.38	pIC50	4200	nM	IC50	J Biol Chem (1998) 273: 32776-32786 [PMID:9830022]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes	F	5.4	pIC50	4000	nM	IC50	Am J Physiol Renal Physiol (2001) 281: F454-F468 [PMID:11502595]
Organic cation transporter 3/Solute carrier family 22 member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073673] [GtoPdb: 1021] [UniProtKB: O75751]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 0.25 uM) in OCT3-expressing HEK293 cells	F	6.54	pIC50	290	nM	IC50	Br J Pharmacol (2002) 136: 829-836 [PMID:12110607]
Organic cation transporter 3/Solute carrier family 22 member 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770033] [GtoPdb: 1021] [UniProtKB: O88446]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (TEA: 20 uM) in OCT3-expressing HRPE cells	F	5.31	pIC50	4900	nM	IC50	J Biol Chem (1998) 273: 32776-32786 [PMID:9830022]
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing HeLa cells	F	5.28	pKi	5300	nM	Ki	Am J Physiol (1996) 270: F326-F331 [PMID:8779894]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Binding affinity towards human testosterone binding globulin.	B	5.34	pKd	5.34	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	6.34	pKd	457.09	nM	Kd	J Med Chem (2008) 51: 2047-2056 [PMID:18330978]
Glucocorticoid receptor in Mouse [GtoPdb: 625] [UniProtKB: P06537]
GtoPdb	-	-	7.2	pIC50	-	-	-	Eur J Pharmacol (1993) 247: 145-54 [PMID:8282004]; FEBS Lett (1999) 464: 9-13 [PMID:10611474]; J Biol Chem (2000) 275: 19041-9 [PMID:10747884]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]