brivaracetam [Ligand Id: 9041] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL607400 (UCB-34714, UCB 34714, Briviact, Brivaracetam)
  • synaptic vesicle glycoprotein 2A/Synaptic vesicle protein 2a in Rat [ChEMBL: CHEMBL4381] [GtoPdb: 2634] [UniProtKB: Q02563]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
synaptic vesicle glycoprotein 2A/Synaptic vesicle protein 2a in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4381] [GtoPdb: 2634] [UniProtKB: Q02563]
ChEMBL Displacement of [3H]-2-[4-(3-azidophenyl)-2-oxo-1-pyrrolidinyl]butanamide from SV2A levetiracetam binding site in Sprague-Dawley rat cerebral cortex membranes after 120 mins by liquid scintillation counting method B 6 pKi <=1000 nM Ki EP-1452524-A1. 2-oxo-1-pyrrolidine derivative and its pharmaceutical uses (2004)
GtoPdb In vitro inhibitory activity against [3H](2S)-2-[4-(3-azidophenyl)-2-oxopyrrolidin-1-yl]butanamide binding to levetiracetam binding site, in rat brain homogenate. - 7 pIC50 100 nM IC50 J Med Chem (2004) 47: 530-49 [PMID:14736235]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]