brivaracetam [Ligand Id: 9041] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL607400 (UCB-34714, UCB 34714, Briviact, Brivaracetam)
  • synaptic vesicle glycoprotein 2A/Synaptic vesicle protein 2a in Rat [ChEMBL: CHEMBL4381] [GtoPdb: 2634] [UniProtKB: Q02563]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
synaptic vesicle glycoprotein 2A/Synaptic vesicle protein 2a in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4381] [GtoPdb: 2634] [UniProtKB: Q02563]
ChEMBL Displacement of [3H]-2-[4-(3-azidophenyl)-2-oxo-1-pyrrolidinyl]butanamide from SV2A levetiracetam binding site in Sprague-Dawley rat cerebral cortex membranes after 120 mins by liquid scintillation counting method B 6 pKi <=1000 nM Ki EP-1452524-A1. 2-oxo-1-pyrrolidine derivative and its pharmaceutical uses (2004)
GtoPdb In vitro inhibitory activity against [3H](2S)-2-[4-(3-azidophenyl)-2-oxopyrrolidin-1-yl]butanamide binding to levetiracetam binding site, in rat brain homogenate. - 7 pIC50 100 nM IC50 J Med Chem (2004) 47: 530-49 [PMID:14736235]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]