ubrogepant [Ligand Id: 10176] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2364638 (MK-1602, Ubrogepant, Ubrelvy)
  • RAMP1/calcitonin receptor-like receptor/Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 in Human [ChEMBL: CHEMBL2107838] [GtoPdb: 5147] [UniProtKB: O60894Q16602]
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  • CGRP receptor in Human [GtoPdb: 48]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
RAMP1/calcitonin receptor-like receptor/Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2107838] [GtoPdb: 5147] [UniProtKB: O60894Q16602]
ChEMBL Displacement of [125I]hCGRP from human recombinant CGRP receptor expressed in HEK293 cell membranes incubated for 3 hrs by scintillation counting method B 10.17 pKi 0.07 nM Ki US-8481556-B2. Piperidinone carboxamide azaindane CGRP receptor antagonists (2013)
CGRP receptor in Human [GtoPdb: 48]
GtoPdb Displacement of [125I]hCGRP from human CGRP receptor expressed in HEK293 cells. - 10.17 pKi 0.07 nM Ki WO2012064910A1. Piperidinone carboxamide azaindane cgrp receptor antagonists (2012)

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]