Quaternary Structure: Complexes |
AMY1 receptor |
CGRP receptor |
Gene and Protein Information ![]() |
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Receptor activity modifying protein | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | References |
Human | 1 | 148 | 2q36-q37.1 | RAMP1 | receptor activity modifying protein 1 | 1,3 |
Mouse | 1 | 148 | 1 D | Ramp1 | receptor (calcitonin) activity modifying protein 1 | 1 |
Rat | 1 | 148 | 9q36 | Ramp1 | receptor activity modifying protein 1 |
Previous and Unofficial Names ![]() |
receptor activity modifying protein 1 |
receptor (G protein-coupled) activity modifying protein 1 |
Database Links ![]() |
|
Alphafold | O60894 (Hs), Q9WTJ5 (Mm), Q9JJ74 (Rn) |
ChEMBL Target | CHEMBL2107838 (Hs), CHEMBL2111189 (Hs), CHEMBL2109240 (Rn) |
DrugBank Target | O60894 (Hs) |
Ensembl Gene | ENSG00000132329 (Hs), ENSMUSG00000034353 (Mm), ENSRNOG00000019926 (Rn) |
Entrez Gene | 10267 (Hs), 51801 (Mm), 58965 (Rn) |
Human Protein Atlas | ENSG00000132329 (Hs) |
KEGG Gene | hsa:10267 (Hs), mmu:51801 (Mm), rno:58965 (Rn) |
OMIM | 605153 (Hs) |
Pharos | O60894 (Hs) |
RefSeq Nucleotide | NM_005855 (Hs), NM_016894 (Mm), NM_031645 (Rn) |
RefSeq Protein | NP_005846 (Hs), NP_058590 (Mm), NP_113833 (Rn) |
UniProtKB | O60894 (Hs), Q9WTJ5 (Mm), Q9JJ74 (Rn) |
Wikipedia | RAMP1 (Hs) |
Protein Comments |
In situ hybridisation studies of the rat brain have shown RAMP1 mRNA to be located predominantly in the cortex, caudate putamen and olfactory tubercles [4]. Immunochemistry shows RAMP1 to be present in the human middle meningeal, middle cerebral, pial and superficial temporal arteries [5]. Northern blotting showed mouse RAMP1 mRNA to be located predominantly in the lung, skeletal muscle and brain [2]. |
1. Derst C, Engel H, Grzeschik K, Daut J. (2000) Genomic structure and chromosome mapping of human and mouse RAMP genes. Cytogenet Cell Genet, 90 (1-2): 115-8. [PMID:11060459]
2. Husmann K, Sexton PM, Fischer JA, Born W. (2000) Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol Cell Endocrinol, 162 (1-2): 35-43. [PMID:10854696]
3. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature, 393 (6683): 333-9. [PMID:9620797]
4. Oliver KR, Kane SA, Salvatore CA, Mallee JJ, Kinsey AM, Koblan KS, Keyvan-Fouladi N, Heavens RP, Wainwright A, Jacobson M et al.. (2001) Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat. Eur J Neurosci, 14 (4): 618-28. [PMID:11556887]
5. Oliver KR, Wainwright A, Edvinsson L, Pickard JD, Hill RG. (2002) Immunohistochemical localization of calcitonin receptor-like receptor and receptor activity-modifying proteins in the human cerebral vasculature. J Cereb Blood Flow Metab, 22 (5): 620-9. [PMID:11973435]
RAMP1. Last modified on 22/10/2014. Accessed on 18/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=51.