pirtobrutinib [Ligand Id: 11628] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Bruton tyrosine kinase in Human [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
| GtoPdb | Inhibition of autophosphorylation of BTK Y223 in the C481S mutant enzyme stably expressed in HEK293 cells | - | 8.06 | pIC50 | 8.8 | nM | IC50 | WO2020028258A1. Spray-dried dispersions and formulations of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro propan-2-yl)-1h-pyrazole-4-carboxamide (2020) |
| GtoPdb | Inhibition of autophosphorylation of BTK Y223 in the wild type enzyme stably expressed in HEK293 cells | - | 8.07 | pIC50 | 8.6 | nM | IC50 | WO2020028258A1. Spray-dried dispersions and formulations of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro propan-2-yl)-1h-pyrazole-4-carboxamide (2020) |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
