example 31 [WO2018183145] [Ligand Id: 12666] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4442295
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GPR6/G-protein coupled receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3714130] [GtoPdb: 85] [UniProtKB: P46095]
GtoPdb Inhibition of GPR6 constitutive cAMP activity in CHO-K1 cells. - 7.1 pEC50 79.4 nM EC50 WO2018183145A1. Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6 (2018)
ChEMBL Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay F 7.1 pEC50 79.43 nM EC50 WO-2018183145-A1. Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6 (2018)

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]