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ChEMBL ligand: CHEMBL4442295 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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GPR6/G-protein coupled receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3714130] [GtoPdb: 85] [UniProtKB: P46095] | ||||||||
GtoPdb | Inhibition of GPR6 constitutive cAMP activity in CHO-K1 cells. | - | 7.1 | pEC50 | 79.4 | nM | EC50 | WO2018183145A1. Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6 (2018) |
ChEMBL | Modulator activity at GPR6 receptor (unknown origin) expressed in CHO-K1 cells assessed as inhibition of constitutive cAMP activity incubated for 45 mins by Eu-cAMP tracer based HTRF Ultra cAMP assay | F | 7.1 | pEC50 | 79.43 | nM | EC50 | WO-2018183145-A1. Piperidinyl- and piperazinyl-substituted heteroaromatic carboxamides as modulators of gpr6 (null) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]