ricolinostat [Ligand Id: 7010] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2364628 (Ricolinostat, ACY-63, ACY-1215)
  • histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
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  • histone deacetylase 10/Histone deacetylase 10 in Human [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
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  • histone deacetylase 11/Histone deacetylase 11 in Human [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2]
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  • histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
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  • histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
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  • histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379Q9Y618]
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  • histone deacetylase 4/Histone deacetylase 4 in Human [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524]
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  • histone deacetylase 5/Histone deacetylase 5 in Human [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6]
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  • histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
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  • histone deacetylase 7/Histone deacetylase 7 in Human [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4]
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  • histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
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  • histone deacetylase 9/Histone deacetylase 9 in Human [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0]
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  • Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
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  • sirtuin 1/NAD-dependent deacetylase sirtuin 1 in Human [ChEMBL: CHEMBL4506] [GtoPdb: 2707] [UniProtKB: Q96EB6]
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  • proteasome 20S subunit beta 5/Proteasome Macropain subunit MB1 in Human [ChEMBL: CHEMBL4662] [GtoPdb: 2406] [UniProtKB: P28074]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL Inhibition of HDAC1 (unknown origin) B 6.73 pIC50 187.9 nM IC50 MedChemComm (2019) 10: 1109-1115
ChEMBL Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells using Boc-Lys-(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay B 7 pIC50 100 nM IC50 Bioorg Med Chem (2018) 26: 1418-1425 [PMID:29500130]
ChEMBL Inhibition of full length recombinant human C-terminal FLAG-tagged HDAC1 expressed in sf9 cells preincubated for 5 mins followed by biotinylated H3K9-Ac substrate addition and measured after 60 mins by HTRF assay B 7.13 pIC50 74 nM IC50 Bioorg Med Chem Lett (2019) 29: 349-352 [PMID:30594434]
ChEMBL Inhibition of HADC1 (unknown origin) B 7.24 pIC50 58 nM IC50 J Med Chem (2020) 63: 23-39 [PMID:31415174]
ChEMBL Inhibition of recombinant human full length C-terminal His/FLAG-tagged HDAC1 expressed in baculovirus infected Sf9 insect cells assessed as decrease in release of 7-amino-4-methoxycoumarin using FTS as substrate preincubated for 10 mins followed by substrate addition measured after 60 sec by microplate reader assay B 7.24 pIC50 58 nM IC50 J Med Chem (2019) 62: 8557-8577 [PMID:31414801]
ChEMBL Inhibition of HDAC1 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assay B 7.24 pIC50 58 nM IC50 J. Med. Chem. (2014) 57: 4009-4022 [PMID:24766560]
ChEMBL Inhibition of full length human recombinant C-terminal FLAG-His-tagged HDAC1 expressed in Sf9 cells using FTS as substrate preincubated for 10 mins followed by substrate addition measured over 30 mins B 7.24 pIC50 58 nM IC50 Eur J Med Chem (2017) 127: 115-127 [PMID:28038324]
ChEMBL Inhibition of HDAC1 (unknown origin) using fluorophore tripeptide as substrate after 30 mins B 7.24 pIC50 58 nM IC50 J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
GtoPdb - - 7.24 pIC50 58 nM IC50 Blood (2012) 119: 2579-89 [PMID:22262760]
ChEMBL Inhibition of human recombinant HDAC1 using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 7.42 pIC50 38 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
ChEMBL Inhibition of HDAC10 (unknown origin) B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
ChEMBL Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter gene-based BRET assay B 5.8 pIC50 1584.89 nM IC50 J Med Chem (2019) 62: 4426-4443 [PMID:30964290]
ChEMBL Inhibition of recombinant HDAC10 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 6.71 pIC50 194 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
ChEMBL Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assay B 6.9 pIC50 125.89 nM IC50 J Med Chem (2019) 62: 4426-4443 [PMID:30964290]
histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2]
ChEMBL Inhibition of recombinant HDAC11 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
ChEMBL Inhibition of recombinant full length human HDAC2 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 17 hrs by electrophoretic mobility shift assay B 6.42 pIC50 379 nM IC50 ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
ChEMBL Inhibition of recombinant HDAC2 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 7.02 pIC50 95 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
ChEMBL Inhibition of full length recombinant human C-terminal His-tagged HDAC2 expressed in baculovirus infected sf9 cells using Boc-Lys-(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay B 7.18 pIC50 66 nM IC50 Bioorg Med Chem (2018) 26: 1418-1425 [PMID:29500130]
ChEMBL Inhibition of HADC2 (unknown origin) B 7.32 pIC50 48 nM IC50 J Med Chem (2020) 63: 23-39 [PMID:31415174]
ChEMBL Inhibition of full length human recombinant C-terminal FLAG-tagged HDAC2 expressed in Sf9 cells using FTS as substrate preincubated for 10 mins followed by substrate addition measured over 30 mins B 7.32 pIC50 48 nM IC50 Eur J Med Chem (2017) 127: 115-127 [PMID:28038324]
ChEMBL Inhibition of HDAC2 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assay B 7.32 pIC50 48 nM IC50 J. Med. Chem. (2014) 57: 4009-4022 [PMID:24766560]
ChEMBL Inhibition of HDAC2 (unknown origin) using fluorophore tripeptide as substrate after 30 mins B 7.32 pIC50 48 nM IC50 J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
GtoPdb - - 7.32 pIC50 48 nM IC50 Blood (2012) 119: 2579-89 [PMID:22262760]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
ChEMBL Inhibition of recombinant HDAC3 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 6.87 pIC50 135 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
GtoPdb - - 7.29 pIC50 51 nM IC50 Blood (2012) 119: 2579-89 [PMID:22262760]
ChEMBL Inhibition of HDAC3 (unknown origin) using fluorophore tripeptide as substrate after 30 mins B 7.29 pIC50 51 nM IC50 J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
ChEMBL Inhibition of HADC3 (unknown origin) B 7.29 pIC50 51 nM IC50 J Med Chem (2020) 63: 23-39 [PMID:31415174]
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379Q9Y618]
GtoPdb - - 7.29 pIC50 51 nM IC50 Blood (2012) 119: 2579-89 [PMID:22262760]
ChEMBL Inhibition of full length recombinant human C-terminal His-tagged HDAC3/N-terminal GST-tagged NCOR2 (395 to 489 residues) expressed in baculovirus infected sf9 cells using Boc-Lys-(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay B 7.43 pIC50 37 nM IC50 Bioorg Med Chem (2018) 26: 1418-1425 [PMID:29500130]
histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524]
ChEMBL Inhibition of recombinant HDAC4 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
ChEMBL Inhibition of HDAC4 (unknown origin) using tripeptide MAZ-1675 as substrate after 30 mins B 5.15 pIC50 7000 nM IC50 J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
ChEMBL Inhibition of recombinant full length human HDAC4 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 1.5 hrs by electrophoretic mobility shift assay B 6 pIC50 >1000 nM IC50 ACS Med Chem Lett (2020) 11: 56-64 [PMID:31938464]
histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6]
ChEMBL Inhibition of recombinant HDAC5 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
ChEMBL Inhibition of HDAC5 (unknown origin) using tripeptide MAZ-1675 as substrate after 30 mins B 5.3 pIC50 5000 nM IC50 J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL Enzyme Assays: Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentration. The HDAC enzymes (purchased from BPS Biosciences) were diluted to 1.5 fold their final concentration in assay buffer. The tripeptide substrate and trypsin at 0.05 uM final concentration were diluted in assay buffer at 6 fold their final concentration. The final enzyme concentrations used in these assays were 3.3 ng/ml (HDAC1), 0.2 ng/ml (HDAC2), 0.08 ng/ml (HDAC3) and 2 ng/ml (HDAC6). The final substrate concentrations used were 16 uM (HDAC1), 10 uM (HDAC2), 17 uM (HDAC3) and 14 uM (HDAC6). B 7.08 pIC50 84 nM IC50 US-8609678-B2. Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof (2013)
ChEMBL Inhibition of HDAC6 (unknown origin) B 7.75 pIC50 17.9 nM IC50 MedChemComm (2019) 10: 1109-1115
ChEMBL Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound followed by Fluor de Lys deacetylase substrate addition by fluorescence method B 7.92 pIC50 12 nM IC50 J Med Chem (2019) 62: 10711-10739 [PMID:31710483]
ChEMBL Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound followed by Fluor de Lys deacetylase substrate addition by fluorescence method B 7.92 pIC50 12 nM IC50 J Med Chem (2019) 62: 10711-10739 [PMID:31710483]
ChEMBL Enzyme Assays: Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were diluted in assay buffer (50 mM HEPES, pH 7.4, 100 mM KCl, 0.001% Tween-20, 0.05% BSA, 20 uM TCEP) to 6 fold their final concentration. The HDAC enzymes (purchased from BPS Biosciences) were diluted to 1.5 fold their final concentration in assay buffer. The tripeptide substrate and trypsin at 0.05 uM final concentration were diluted in assay buffer at 6 fold their final concentration. The final enzyme concentrations used in these assays were 3.3 ng/ml (HDAC1), 0.2 ng/ml (HDAC2), 0.08 ng/ml (HDAC3) and 2 ng/ml (HDAC6). The final substrate concentrations used were 16 uM (HDAC1), 10 uM (HDAC2), 17 uM (HDAC3) and 14 uM (HDAC6). B 8 pIC50 10 nM IC50 US-8609678-B2. Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof (2013)
ChEMBL Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells using Boc-Lys-(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay B 8.05 pIC50 9 nM IC50 Bioorg Med Chem (2018) 26: 1418-1425 [PMID:29500130]
ChEMBL Inhibition of human recombinant HDAC6 using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 8.05 pIC50 9 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
ChEMBL Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells preincubated for 5 mins followed by biotinylated H3K9-Ac substrate addition and measured after 60 mins by HTRF assay B 8.3 pIC50 5 nM IC50 Bioorg Med Chem Lett (2019) 29: 349-352 [PMID:30594434]
ChEMBL Inhibition of HDAC6 (unknown origin) using fluorophore tripeptide as substrate after 30 mins B 8.33 pIC50 4.7 nM IC50 J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
ChEMBL Inhibition of HADC6 (unknown origin) B 8.33 pIC50 4.7 nM IC50 J Med Chem (2020) 63: 23-39 [PMID:31415174]
ChEMBL Inhibition of human HDAC6 using (Z-(Ac)Lys-AMC) as substrate after 90 mins by fluorescence analysis B 8.33 pIC50 4.7 nM IC50 Eur J Med Chem (2019) 162: 321-333 [PMID:30448419]
ChEMBL Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected insect cells using RHK-K(Ac)-AMC as substrate after 90 mins by fluorescence assay B 8.33 pIC50 4.7 nM IC50 J Med Chem (2018) 61: 905-917 [PMID:29304284]
ChEMBL Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells assessed as decrease in release of 7-amino-4-methoxycoumarin using FTS as substrate preincubated for 10 mins followed by substrate addition measured after 60 sec by microplate reader assay B 8.33 pIC50 4.7 nM IC50 J Med Chem (2019) 62: 8557-8577 [PMID:31414801]
ChEMBL Inhibition of full length human recombinant N-terminal GST-tagged HDAC6 expressed in Sf9 cells using FTS as substrate preincubated for 10 mins followed by substrate addition measured over 30 mins B 8.33 pIC50 4.7 nM IC50 Eur J Med Chem (2017) 127: 115-127 [PMID:28038324]
ChEMBL Inhibition of HDAC6 (unknown origin) B 8.33 pIC50 4.7 nM IC50 Eur J Med Chem (2018) 150: 506-524 [PMID:29549837]
ChEMBL Inhibition of HDAC6 (unknown origin) using RHKK(Ac) (379 to 382) p53 peptide as substrate by fluorescence assay B 8.33 pIC50 4.7 nM IC50 J. Med. Chem. (2014) 57: 4009-4022 [PMID:24766560]
GtoPdb - - 8.33 pIC50 4.7 nM IC50 Blood (2012) 119: 2579-89 [PMID:22262760]
histone deacetylase 7/Histone deacetylase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4]
ChEMBL Inhibition of recombinant HDAC7 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
ChEMBL Inhibition of HDAC7 (unknown origin) using tripeptide MAZ-1675 as substrate after 30 mins B 5.85 pIC50 1400 nM IC50 J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
ChEMBL Inhibition of full length recombinant human C-terminal His-tagged HDAC8 expressed in baculovirus infected sf9 cells using Boc-Lys-(TFA)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay B 5.3 pIC50 >5000 nM IC50 Bioorg Med Chem (2018) 26: 1418-1425 [PMID:29500130]
ChEMBL Inhibition of human recombinant HDAC8 using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 6.6 pIC50 254 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
GtoPdb - - 7 pIC50 100 nM IC50 Blood (2012) 119: 2579-89 [PMID:22262760]
ChEMBL Inhibition of HDAC8 (unknown origin) using tripeptide MAZ-1675 as substrate after 30 mins B 7 pIC50 100 nM IC50 J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
ChEMBL Inhibition of HADC8 (unknown origin) B 7 pIC50 100 nM IC50 J Med Chem (2020) 63: 23-39 [PMID:31415174]
histone deacetylase 9/Histone deacetylase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0]
ChEMBL Inhibition of HDAC9 (unknown origin) using tripeptide MAZ-1675 as substrate after 30 mins B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2013) 56: 6297-6313 [PMID:23627282]
ChEMBL Inhibition of recombinant HDAC9 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysis B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2016) 59: 1455-1470 [PMID:26443078]
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
ChEMBL Inhibition of recombinant human LTA4H Epoxide Hydrolase expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by addition of LTA4 as substrate measured after 15 mins by reverse-phase HPLC analysis B 5 pIC50 >10000 nM IC50 J Med Chem (2017) 60: 1817-1828 [PMID:28218840]
sirtuin 1/NAD-dependent deacetylase sirtuin 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4506] [GtoPdb: 2707] [UniProtKB: Q96EB6]
ChEMBL Inhibition of recombinant human N-terminal His-tagged SIRT1 (1 to 747 end residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate after 30 mins in presence of NAD+ by fluorescence assay B 5 pIC50 >10000 nM IC50 J Med Chem (2018) 61: 905-917 [PMID:29304284]
proteasome 20S subunit beta 5/Proteasome Macropain subunit MB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4662] [GtoPdb: 2406] [UniProtKB: P28074]
ChEMBL Inhibition of chymotrypsin-like activity of 20S proteasome in imatinib-resistant human SUP-B15 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Glo assay B 4.6 pIC50 >25000 nM IC50 J Med Chem (2018) 61: 10299-10309 [PMID:30365892]
ChEMBL Inhibition of chymotrypsin-like activity of 20S proteasome in human SEM cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Glo assay B 4.6 pIC50 >25000 nM IC50 J Med Chem (2018) 61: 10299-10309 [PMID:30365892]
ChEMBL Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Glo assay B 4.6 pIC50 >25000 nM IC50 J Med Chem (2018) 61: 10299-10309 [PMID:30365892]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]