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Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | - | 347 | 3p25.1 | HDAC11 | histone deacetylase 11 | |
| Mouse | - | 347 | 6 D1 | Hdac11 | histone deacetylase 11 | |
| Rat | - | - | 4q34 | Hdac11 | histone deacetylase 11 | |
| Database Links |
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| Alphafold | Q96DB2 (Hs), Q91WA3 (Mm) |
| BRENDA | 3.5.1.98 |
| CATH/Gene3D | 3.40.800.20 |
| ChEMBL Target | CHEMBL3310 (Hs) |
| Ensembl Gene | ENSG00000163517 (Hs), ENSMUSG00000034245 (Mm), ENSRNOG00000006824 (Rn) |
| Entrez Gene | 79885 (Hs), 232232 (Mm), 297453 (Rn) |
| Human Protein Atlas | ENSG00000163517 (Hs) |
| KEGG Enzyme | 3.5.1.98 |
| KEGG Gene | hsa:79885 (Hs), mmu:232232 (Mm), rno:297453 (Rn) |
| OMIM | 607226 (Hs) |
| Pharos | Q96DB2 (Hs) |
| RefSeq Nucleotide | NM_024827 (Hs), NM_144919 (Mm), NM_001106610 (Rn) |
| RefSeq Protein | NP_079103 (Hs), NP_659168 (Mm), NP_001100080 (Rn) |
| UniProtKB | Q96DB2 (Hs), Q91WA3 (Mm) |
| Wikipedia | HDAC11 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Inhibitor Comments | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Vorinostat has high affinity for HDACs 2, 3, 6, 9, 10 and 11, but 10-fold lower affinity for HDAC8 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| General Comments |
| HDAC11 is an atypical histone deacetylase and is the only Class IV member. |
1. Arts J, King P, Mariën A, Floren W, Beliën A, Janssen L, Pilatte I, Roux B, Decrane L, Gilissen R et al.. (2009) JNJ-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. Clin Cancer Res, 15 (22): 6841-51. [PMID:19861438]
2. Ellis JD, Neil DA, Inston NG, Jenkinson E, Drayson MT, Hampson P, Shuttleworth SJ, Ready AR, Cobbold M. (2016) Inhibition of Histone Deacetylase 6 Reveals a Potent Immunosuppressant Effect in Models of Transplantation. Transplantation, 100 (8): 1667-74. [PMID:27222932]
3. Qian C, Lai CJ, Bao R, Wang DG, Wang J, Xu GX, Atoyan R, Qu H, Yin L, Samson M et al.. (2012) Cancer network disruption by a single molecule inhibitor targeting both histone deacetylase activity and phosphatidylinositol 3-kinase signaling. Clin Cancer Res, 18 (15): 4104-13. [PMID:22693356]
4. Shen S, Hadley M, Ustinova K, Pavlicek J, Knox T, Noonepalle S, Tavares MT, Zimprich CA, Zhang G, Robers MB et al.. (2019) Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J Med Chem, 62 (18): 8557-8577. [PMID:31414801]
5. Wang H, Lim ZY, Zhou Y, Ng M, Lu T, Lee K, Sangthongpitag K, Goh KC, Wang X, Wu X et al.. (2010) Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett, 20 (11): 3314-21. [PMID:20451378]
3.5.1.- Histone deacetylases (HDACs): histone deacetylase 11. Last modified on 13/09/2019. Accessed on 25/01/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2615.
