CR3022   Click here for help

GtoPdb Ligand ID: 11076

Compound class: Antibody
Comment: CR3022 is a monoclonal antibody that binds Spike protein (S) of SARS-CoV and SARS-CoV-2 [2-3,5]. It was developed from a single chain Fv phage display library derived from lymphocytes from the convalescent plasma of a SARS-CoV patient, and reconstructed into IgG1 format [2]. CR3022 does not compete for binding with antibodies that bind to the ACE2 RBD of S, and acts allosterically to reduce binding to ACE2 [1]. Cryo-EM analysis shows that CR3022 Fab disrupts S conformation, so as to promote conversion to the fusion-incompetent post-fusion state, thus incapacitating the virus's ACE2-dependent infection mechanism [1]. Elucidating the protein-protein interactions that determine SARS-CoV-2/ACE2 binding and viral infection will help to identify ways in which this crucial interaction might the targeted for therapeutic development [4].
Click here for help
Classification Click here for help
Compound class Antibody
Database Links Click here for help
GtoPdb PubChem SID 434122137