tipiracil [Ligand Id: 8696] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL235668 (MA-1, Tipiracil, TPI (freebase)) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Thymidine phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3106] [UniProtKB: P19971] | ||||||||
| ChEMBL | Competitive inhibition of thymidine phosphorylase (unknown origin) | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2019) 62: 1231-1245 [PMID:30615449] |
| ChEMBL | Inhibitory activity against human thymidine phosphorylase | B | 7.77 | pKi | 17 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 3705-3709 [PMID:14552762] |
| ChEMBL | Binding affinity towards recombinant thymidine phosphorylase TP | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 107-110 [PMID:12467627] |
| ChEMBL | Inhibition of human placental thymidine phosphorylase | B | 8.68 | pKi | 2.1 | nM | Ki | J Med Chem (2007) 50: 6016-6023 [PMID:17963370] |
| ChEMBL | Inhibition of human recombinant thymidine phosphorylase expressed in V79 cells | B | 8.89 | pKi | 1.3 | nM | Ki | J Med Chem (2007) 50: 6016-6023 [PMID:17963370] |
| ChEMBL | Inhibitory concentration against human thymidine phosphorylase TP | B | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 107-110 [PMID:12467627] |
| ChEMBL | Inhibition of thymidine phosphorylase (unknown origin) | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2019) 62: 1231-1245 [PMID:30615449] |
| ChEMBL | Inhibitory activity against Escherichia coli thymidine phosphorylase | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3705-3709 [PMID:14552762] |
| Thymidine phosphorylase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3726] [UniProtKB: P07650] | ||||||||
| ChEMBL | Inhibition of Escherichia coli thymidine phosphorylase | B | 7.46 | pKi | 35 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 1648-1651 [PMID:20138520] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
