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ChEMBL ligand: CHEMBL209148 (BMS-509744) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of Cdk2 | B | 4.54 | pIC50 | 29000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
ChEMBL | Inhibition of EGFR | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3-beta | B | 4.44 | pIC50 | 36000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
ChEMBL | Inhibition of IKK-beta | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
ChEMBL | Inhibition of Insulin receptor | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
ChEMBL | Inhibition of ERK1 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
ChEMBL | Inhibition of Akt1 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
ChEMBL | Inhibition of Btk | B | 5.39 | pIC50 | 4100 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
ChEMBL | Inhibition of Fyn | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
ChEMBL | Inhibition of ITK | B | 7.8 | pKi | 16 | nM | Ki | Chem Biol (2005) 12: 621-637 [PMID:15975507] |
GtoPdb | - | - | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-12 [PMID:16682193] |
ChEMBL | Inhibition of Itk | B | 7.72 | pIC50 | 19 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
ChEMBL | Inhibition of human ITK using poly-Glu-Tyr (4:1) as substrate incubated for 1 hr by ELISA | B | 7.99 | pIC50 | 10.3 | nM | IC50 | J Med Chem (2022) 65: 2694-2709 [PMID:35099969] |
LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
ChEMBL | Inhibition of LCK | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
ChEMBL | Inhibition of Syk | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680] | ||||||||
ChEMBL | Inhibition of Tec | B | 4.77 | pIC50 | 17000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681] | ||||||||
ChEMBL | Inhibition of Txk | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
ChEMBL | Inhibition of ZAP70 | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 3706-3712 [PMID:16682193] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]