Synonyms: AZ-7371 | compound 1 [PMID:24957839] | TBA7371
Compound class:
Synthetic organic
Comment: TBA-7371 was identified in a lead optimization study of a series of 1,4-azaindoles, a novel class of antibacterial compounds [1-3]. It has potent antimycobacterial activity and is under clinical evaluation as a treatment for tuberculosis (TB). TBA-7371 is a non-covalent inhibitor of decaprenylphosphoryl-beta-D-ribose oxidase (DprE1), an essential mycobacterial cell wall biosynthesis enzyme [1].
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
N-(2-hydroxyethyl)-1-[(6-methoxy-5-methylpyrimidin-4-yl)methyl]-6-methylpyrrolo[3,2-b]pyridine-3-carboxamide |
Synonyms |
AZ-7371 | compound 1 [PMID:24957839] | TBA7371 |
Database Links | |
BindingDB Ligand | 50019654 |
CAS Registry No. | 1494675-86-3 (source: Scifinder) |
ChEMBL Ligand | CHEMBL3109802 |
DrugBank Ligand | DB16243 |
GtoPdb PubChem SID | 491299915 |
PubChem CID | 72792692 |
Search Google for chemical match using the InChIKey | VDRYGTNDKXIPSK-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | VDRYGTNDKXIPSK |
UniChem Compound Search for chemical match using the InChIKey | VDRYGTNDKXIPSK-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | VDRYGTNDKXIPSK-UHFFFAOYSA-N |