Synonyms: AZ-7371 | compound 1 [PMID:24957839] | TBA7371
Compound class:
Synthetic organic
Comment: TBA-7371 was identified in a lead optimization study of a series of 1,4-azaindoles, a novel class of antibacterial compounds [1-3]. It has potent antimycobacterial activity and is under clinical evaluation as a treatment for tuberculosis (TB). TBA-7371 is a non-covalent inhibitor of decaprenylphosphoryl-beta-D-ribose oxidase (DprE1), an essential mycobacterial cell wall biosynthesis enzyme [1].
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Bioactivity Comments |
The IC50 against Mycobacterium tuberculosis DprE1 is 0.01 μM [1]. |