ChEMBL ligand: CHEMBL298517 ((1R,2R,4S)-Epibatidine, (+)-Epibatidine)
nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor β4 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Rat [ChEMBL: CHEMBL1907593] [GtoPdb: 464, 474] [UniProtKB: P04757, P12392] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681] nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat [ChEMBL: CHEMBL1907596] [GtoPdb: 465, 472] [UniProtKB: P09483, P12390] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544] nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941] There should be some charts here, you may need to enable JavaScript!
Nicotinic acetylcholine receptor alpha 5 subunit in Musca domestica [ChEMBL: CHEMBL2366408] [UniProtKB: A9XFY4] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor β4 subunit/Neuronal acetylcholine receptor; alpha3/beta4 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907593] [GtoPdb: 464, 474] [UniProtKB: P04757, P12392]
ChEMBL	Displacement of [3H]epibatidine from Alpha3 Beta4 Nicotinic acetylcholine receptor of rat brain homogenates	B	9.42	pKi	0.38	nM	Ki	J. Med. Chem. (2005) 48: 5123-5130 [PMID:16078832]
ChEMBL	Effective concentration against alpha3-beta4 nicotinic acetylcholine receptor expressed in IMR32 cell	B	6.15	pEC50	700	nM	EC50	J. Med. Chem. (2005) 48: 5123-5130 [PMID:16078832]
nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681]
ChEMBL	Binding affinity to alpha4beta2 nAChR (unknown origin)	B	10.35	pKi	0.04	nM	Ki	Eur. J. Med. Chem. (2015) 103: 429-437 [PMID:26383127]
ChEMBL	Displacement of [3H]epibatidine from alpha-4-beta-2 nAChR	B	10.59	pKi	0.03	nM	Ki	J. Med. Chem. (2007) 50: 6383-6391 [PMID:17994682]
nicotinic acetylcholine receptor α4 subunit/nicotinic acetylcholine receptor β2 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907596] [GtoPdb: 465, 472] [UniProtKB: P09483, P12390]
ChEMBL	in vitro binding affinity by inhibiting [3H]cytisine binding in rat brain tissue at Nicotinic acetylcholine receptor alpha4-beta2	B	9.8	pKi	0.16	nM	Ki	J. Med. Chem. (2002) 45: 3041-3047 [PMID:12086489]
ChEMBL	Inhibition of [3H]nicotine binding to alpha4-beta2 nACh receptor from rat membranes from ref 15	B	10.26	pKi	0.06	nM	Ki	Bioorg. Med. Chem. Lett. (2004) 14: 1889-1896 [PMID:15050621]
ChEMBL	Displacement of [3H]-cytisine from Alpha4-beta2 Nicotinic acetylcholine receptor of rat brain homogenates	B	10.3	pKi	0.05	nM	Ki	J. Med. Chem. (2005) 48: 5123-5130 [PMID:16078832]
ChEMBL	Inhibition of [3H]nicotine binding to alpha4-beta2 nACh receptor from rat membranes from ref 14	B	10.35	pKi	0.04	nM	Ki	Bioorg. Med. Chem. Lett. (2004) 14: 1889-1896 [PMID:15050621]
ChEMBL	Non-specific binding in presence of 300 uM nicotine at nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortex membranes	B	10.35	pKi	0.04	nM	Ki	J. Med. Chem. (2001) 44: 2229-2237 [PMID:11405659]
ChEMBL	Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex after 4 hrs by scintillation counting	B	10.59	pKi	0.03	nM	Ki	J. Nat. Prod. (2010) 73: 306-312 [PMID:20038125]
ChEMBL	Displacement of [3H]epibatidine from alpha-4-beta-2 nACHR in rat cerebral cortex	B	10.59	pKi	0.03	nM	Ki	J. Med. Chem. (2006) 49: 3244-3250 [PMID:16722642]
ChEMBL	Inhibition of [3H]epibatidine binding at the nicotinic acetylcholine receptor alpha4-beta2 in male rat cerebral cortex	B	10.59	pKi	0.03	nM	Ki	J. Med. Chem. (2001) 44: 2229-2237 [PMID:11405659]
ChEMBL	Inhibition of alpha beta[3H]epibatidine binding to Nicotinic acetylcholine receptor alpha4-beta2 of rat cerebral cortex	B	10.7	pKi	0.02	nM	Ki	J. Med. Chem. (2004) 47: 4588-4594 [PMID:15317468]
ChEMBL	Displacement of [3H]Nicotine from alpha4beta2 nAChR in rat cortical membranes	B	10.72	pKi	0.02	nM	Ki	Bioorg. Med. Chem. Lett. (2006) 16: 5493-5497 [PMID:16934977]
ChEMBL	Inhibition of [3H]nicotine binding to alpha4-beta2 nACh receptor from rat membranes from ref 16	B	10.74	pKi	0.02	nM	Ki	Bioorg. Med. Chem. Lett. (2004) 14: 1889-1896 [PMID:15050621]
ChEMBL	Displacement of [3H]epibatidine from alpha4beta2 nAChR in rat cerebral cortex after 4 hrs by scintillation counting	B	10.74	pKi	0.02	nM	Ki	J. Nat. Prod. (2010) 73: 306-312 [PMID:20038125]
ChEMBL	In vitro binding affinity by inhibiting [3H]dopamine release in rat brain tissue at Nicotinic acetylcholine receptor alpha4-beta2	F	8.89	pEC50	1.3	nM	EC50	J. Med. Chem. (2002) 45: 3041-3047 [PMID:12086489]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
ChEMBL	Agonist activity at human recombinant alpha7 nAChR expressed in rat GH3 cells by calcium influx assay	F	7.4	pEC50	39.81	nM	EC50	Bioorg. Med. Chem. Lett. (2009) 19: 1287-1291 [PMID:19208472]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941]
ChEMBL	Displacement of [125I-alpha]-Bungarotoxin from alpha-7 nAChR in rat hippocampal membranes	B	8.31	pKi	4.9	nM	Ki	Bioorg. Med. Chem. Lett. (2006) 16: 5493-5497 [PMID:16934977]
Nicotinic acetylcholine receptor alpha 5 subunit in Musca domestica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366408] [UniProtKB: A9XFY4]
ChEMBL	Displacement of [3HIMI from nicotinic acetylcholine receptor in Musca domestica (house fly) head membranes incubated for 60 min by liquid scintillation counting method	B	5.55	pIC50	2790	nM	IC50	Biosci. Biotechnol. Biochem. (2003) 67: 980-988 [PMID:12834274]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]