epibatidine   Click here for help

GtoPdb Ligand ID: 5348

Synonyms: (+)-epibatidine | CMI 488
Compound class: Natural product
Comment: Epibatidine is a nAChR agonist isolated from the skin of the frog Epipedobates tricolor. This compound is extremely toxic, so less harmful derivatives have been developed.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 24.92
Molecular weight 208.08
XLogP 1.75
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Clc1ccc(cn1)C1CC2NC1CC2
Isomeric SMILES Clc1ccc(cn1)[C@@H]1C[C@@H]2N[C@H]1CC2
InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8-,9+,10+/m1/s1
InChI Key NLPRAJRHRHZCQQ-UTLUCORTSA-N
Classification Click here for help
Compound class Natural product
IUPAC Name Click here for help
(1S,2S,4R)-2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane
Synonyms Click here for help
(+)-epibatidine | CMI 488
Database Links Click here for help
CAS Registry No. 140111-52-0
ChEMBL Ligand CHEMBL298517
DrugBank Ligand DB07720
GtoPdb PubChem SID 178102010
PubChem CID 3073763
Search Google for chemical match using the InChIKey NLPRAJRHRHZCQQ-UTLUCORTSA-N
Search Google for chemicals with the same backbone NLPRAJRHRHZCQQ
UniChem Compound Search for chemical match using the InChIKey NLPRAJRHRHZCQQ-UTLUCORTSA-N
UniChem Connectivity Search for chemical match using the InChIKey NLPRAJRHRHZCQQ-UTLUCORTSA-N
Wikipedia Epibatidine