Nω-hydroxy-nor-L-arginine [Ligand Id: 5091] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1234777 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Arginase I/Arginase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075097] [GtoPdb: 1244] [UniProtKB: P05089] | ||||||||
| ChEMBL | Binding affinity to human Arg1 at pH 8.5 | B | 6.29 | pKd | 517 | nM | Kd | Bioorg Med Chem (2020) 28: 115658-115658 [PMID:32828425] |
| ChEMBL | Inhibition of human Arginase I assessed as dissociation constant by ITC analysis | B | 7.3 | pKd | 50 | nM | Kd | Bioorg Med Chem Lett (2023) 84: 129193-129193 [PMID:36822300] |
| ChEMBL | Binding affinity to arginase 1 (unknown origin) | B | 7.33 | pKd | 47 | nM | Kd | Bioorg Med Chem Lett (2018) 28: 319-329 [PMID:29326017] |
| ChEMBL | Inhibition of recombinant human liver ARGI using L-arginine as substrate incubated for 60 mins by spectroscopic analysis | B | 5.22 | pIC50 | 6000 | nM | IC50 | RSC Med Chem (2020) 11: 559-568 [PMID:33479657] |
| ChEMBL | Inhibition of human ARG1 | B | 5.7 | pIC50 | 2000 | nM | IC50 | Eur J Med Chem (2018) 157: 582-598 [PMID:30125720] |
| ChEMBL | Inhibition of human arginase 1 measured after 60 mins by calorimetric assay | B | 5.77 | pIC50 | 1700 | nM | IC50 | Bioorg Med Chem (2022) 72: 116970-116970 [PMID:36063653] |
| ChEMBL | Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as substrate in presence of MnSO4 incubated for 60 mins by o-phthaldialdehyde/N-(1-naphthyl)ethylene-diamine dihydrochloride reagent based colorimetric assay | B | 5.87 | pIC50 | 1360 | nM | IC50 | J Med Chem (2019) 62: 8164-8177 [PMID:31408339] |
| ChEMBL | Binding affinity to human ARG1 assessed as dissociation constant | B | 6.29 | pIC50 | 517 | nM | IC50 | Eur J Med Chem (2021) 218: 113356-113356 [PMID:33773287] |
| ChEMBL | Inhibition of recombinant human ARG1 expressed in Escherichia coli using L-arginine hydrochloride as substrate incubated for 1 hr by colorimetric assay | B | 6.35 | pIC50 | 450 | nM | IC50 | Eur J Med Chem (2021) 218: 113356-113356 [PMID:33773287] |
| Arginase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075060] [UniProtKB: Q2KJ64] | ||||||||
| ChEMBL | Inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by spectroscopic analysis | B | 5.57 | pIC50 | 2700 | nM | IC50 | RSC Med Chem (2020) 11: 559-568 [PMID:33479657] |
| Arginase I/Arginase-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232699] [GtoPdb: 1244] [UniProtKB: P07824] | ||||||||
| ChEMBL | Inhibition of Sprague-Dawley rat liver arginase 1 assessed as inhibition constant | B | 6.3 | pKi | 500 | nM | Ki | Bioorg Med Chem (2022) 72: 116970-116970 [PMID:36063653] |
| ChEMBL | Inhibition of Sprague-Dawley rat liver arginase 1 | B | 4.3 | pIC50 | 50000 | nM | IC50 | Bioorg Med Chem (2022) 72: 116970-116970 [PMID:36063653] |
| ChEMBL | Inhibition of rat liver arginase | B | 5.7 | pIC50 | 2000 | nM | IC50 | Eur J Med Chem (2014) 76: 132-144 [PMID:24583353] |
| ChEMBL | Inhibition of rat Arg1 at pH 7.4 | B | 6.1 | pIC50 | 800 | nM | IC50 | Bioorg Med Chem (2020) 28: 115658-115658 [PMID:32828425] |
| ChEMBL | Inhibition of rat ARG1 | B | 6.1 | pIC50 | 800 | nM | IC50 | Eur J Med Chem (2021) 218: 113356-113356 [PMID:33773287] |
| Arginase II/Arginase-2, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795148] [GtoPdb: 1245] [UniProtKB: P78540] | ||||||||
| ChEMBL | Inhibition of arginase 2 (unknown origin) | B | 7.29 | pKi | 51 | nM | Ki | Bioorg Med Chem Lett (2018) 28: 319-329 [PMID:29326017] |
| ChEMBL | Inhibition of human Arg2 at pH 7.5 | B | 7.29 | pKi | 51 | nM | Ki | Bioorg Med Chem (2020) 28: 115658-115658 [PMID:32828425] |
| ChEMBL | Binding affinity to human ARG2 assessed as inhibition constant | B | 7.29 | pIC50 | 51 | nM | IC50 | Eur J Med Chem (2021) 218: 113356-113356 [PMID:33773287] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
