Nω-hydroxy-nor-L-arginine [Ligand Id: 5091] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1234777 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Arginase I/Arginase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075097] [GtoPdb: 1244] [UniProtKB: P05089] | ||||||||
| ChEMBL | Binding affinity to human Arg1 at pH 8.5 | B | 6.29 | pKd | 517 | nM | Kd | Bioorg Med Chem (2020) 28: 115658-115658 [PMID:32828425] |
| ChEMBL | Binding affinity to arginase 1 (unknown origin) | B | 7.33 | pKd | 47 | nM | Kd | Bioorg Med Chem Lett (2018) 28: 319-329 [PMID:29326017] |
| ChEMBL | Inhibition of recombinant human liver ARGI using L-arginine as substrate incubated for 60 mins by spectroscopic analysis | B | 5.22 | pIC50 | 6000 | nM | IC50 | RSC Med Chem (2020) 11: 559-568 [PMID:33479657] |
| ChEMBL | Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as substrate in presence of MnSO4 incubated for 60 mins by o-phthaldialdehyde/N-(1-naphthyl)ethylene-diamine dihydrochloride reagent based colorimetric assay | B | 5.87 | pIC50 | 1360 | nM | IC50 | J Med Chem (2019) 62: 8164-8177 [PMID:31408339] |
| Arginase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075060] [UniProtKB: Q2KJ64] | ||||||||
| ChEMBL | Inhibition of recombinant bovine liver ARGI using L-arginine as substrate incubated for 60 mins by spectroscopic analysis | B | 5.57 | pIC50 | 2700 | nM | IC50 | RSC Med Chem (2020) 11: 559-568 [PMID:33479657] |
| Arginase I/Arginase-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232699] [GtoPdb: 1244] [UniProtKB: P07824] | ||||||||
| ChEMBL | Inhibition of rat liver arginase | B | 5.7 | pIC50 | 2000 | nM | IC50 | Eur J Med Chem (2014) 76: 132-144 [PMID:24583353] |
| ChEMBL | Inhibition of rat Arg1 at pH 7.4 | B | 6.1 | pIC50 | 800 | nM | IC50 | Bioorg Med Chem (2020) 28: 115658-115658 [PMID:32828425] |
| Arginase II/Arginase-2, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795148] [GtoPdb: 1245] [UniProtKB: P78540] | ||||||||
| ChEMBL | Inhibition of arginase 2 (unknown origin) | B | 7.29 | pKi | 51 | nM | Ki | Bioorg Med Chem Lett (2018) 28: 319-329 [PMID:29326017] |
| ChEMBL | Inhibition of human Arg2 at pH 7.5 | B | 7.29 | pKi | 51 | nM | Ki | Bioorg Med Chem (2020) 28: 115658-115658 [PMID:32828425] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
