ChEMBL ligand: CHEMBL4650332 (Etavopivat, Ft-4202, FT-4202)
Probable ubiquitin carboxyl-terminal hydrolase FAF-X in Human [ChEMBL: CHEMBL2406899] [UniProtKB: Q93008] There should be some charts here, you may need to enable JavaScript!
pyruvate kinase L/R in Human [GtoPdb: 3007] [UniProtKB: P30613] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Probable ubiquitin carboxyl-terminal hydrolase FAF-X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2406899] [UniProtKB: Q93008]
ChEMBL	Inhibition of USP9X (unknown origin) using Ubiquitin-Rhoadmine 110 as substrate preincubated for 30 mins followed by substrate addition and measured after 11 mins by fluorescence assay	B	5.7	pIC50	2000	nM	IC50	WO-2020061261-A1. Inhibiting ubiquitin specific peptidase 9x (null)
pyruvate kinase L/R in Human [GtoPdb: 3007] [UniProtKB: P30613]
GtoPdb	Activation of wild-type PKR by etavopivat in mature, purified human RBCs	-	6.95	pEC50	113	nM	EC50	J Pharmacol Exp Ther (2022) 380: 210-219 [PMID:35031585]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]