BMS-582949 [Ligand Id: 7838] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1230065 (PS-540446, BMS-582949)
  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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  • mitogen-activated protein kinase 11/MAP kinase p38 beta in Human [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 mins B 7.89 pIC50 13 nM IC50 J. Med. Chem. (2010) 53: 6629-6639 [PMID:20804198]
GtoPdb - - 7.89 pIC50 13 nM IC50 J. Med. Chem. (2010) 53: 6629-39 [PMID:20804198]
mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759]
ChEMBL Inhibition of p38beta (unknown origin) B 7.21 pIC50 62 nM IC50 Bioorg. Med. Chem. Lett. (2013) 23: 4120-4126 [PMID:23746475]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]