UK-356202 [Ligand Id: 6543] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL111576 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749] | ||||||||
| ChEMBL | Inhibitory activity against human urokinase-type plasminogen activator was evaluated using S-2444 as substrate | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3227-3230 [PMID:15149680] |
| ChEMBL | Inhibition of human uPA using S-2444 as substrate | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2015) 58: 9238-9257 [PMID:26575094] |
| GtoPdb | - | - | 7.4 | pIC50 | 37 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 3227-30 [PMID:15149680] |
| ChEMBL | Inhibition of uPA | B | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2008) 51: 183-186 [PMID:18163548] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
