ChEMBL ligand: CHEMBL2178284
Enoyl-[acyl-carrier-protein] reductase in Escherichia coli [ChEMBL: CHEMBL1857] [UniProtKB: P0AEK4] There should be some charts here, you may need to enable JavaScript!
Enoyl-[acyl-carrier-protein] reductase (FabI) in S.aureus [ChEMBL: CHEMBL3994] [UniProtKB: Q6GI75] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Enoyl-[acyl-carrier-protein] reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1857] [UniProtKB: P0AEK4]
ChEMBL	Inhibition of Escherichia coli FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rate	B	7.24	pIC50	58	nM	IC50	Eur J Med Chem (2020) 208: 112757-112757 [PMID:32883635]
ChEMBL	Inhibition of Escherichia coli DH5alpha FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rate	B	7.24	pIC50	58	nM	IC50	Eur J Med Chem (2020) 208: 112757-112757 [PMID:32883635]
Enoyl-[acyl-carrier-protein] reductase (FabI) in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3994] [UniProtKB: Q6GI75]
ChEMBL	Inhibition of Staphylococcus aureus recombinant FabI using trans-2-octenoyl N-acetylcysteamine thioester as substrate preincubated for 60 mins	B	7.92	pIC50	12	nM	IC50	J Med Chem (2012) 55: 9914-9928 [PMID:23092194]
ChEMBL	Inhibition of Staphylococcus aureus FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rate	B	7.92	pIC50	12	nM	IC50	Eur J Med Chem (2020) 208: 112757-112757 [PMID:32883635]
ChEMBL	Inhibition of Staphylococcus aureus ATCC 29213 FabI in the presence of NADH using crotonyl CoA as substrate by measuring NADH consumption rate	B	7.92	pIC50	12	nM	IC50	Eur J Med Chem (2020) 208: 112757-112757 [PMID:32883635]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]